Assessing cognitive biases induced by acute formalin or hotplate treatment: an animal study using affective bias test.

Pain, a universal and burdensome condition, influences numerous individuals worldwide. It encompasses sensory, emotional, and cognitive facets, with recent research placing a heightened emphasis on comprehending pain's impact on emotion and cognition. Cognitive bias, which encompasses attentional bias, interpretation bias, and memory bias, signifies the presence of cognitive distortions influenced by emotional factors. It has gained significant prominence in pain-related research. Human studies have shown that individuals experiencing pain exhibit cognitive bias. Similarly, animal studies have demonstrated cognitive bias in pain-induced states across various species and disease models. In this study, we aimed to investigate the memory bias displayed by rats experiencing acute pain, using the affective bias test (ABT) as a tool and administering either hotplate or formalin to induce acute pain. Our data showed that rats demonstrated a significant preference for the control treatment-related substrate over the substrate associated with formalin treatment (p < 0.001), an indication of the prominent memory bias stimulated by acute formalin injections. However, when exposed to substrates related to hotplate treatment and control treatment, the acute pain induced by the hotplate treatment failed to generate a statistically significant choice bias in rats (p = 0.674). Our study demonstrates that the negative emotions associated with acute pain can be reflected by memory bias in ABT, at least for formalin-induced acute pain. This finding will augment our comprehension of the emotional and cognitive aspects of acute pain.

Cross-script phonological activation in Chinese-English bilinguals: The effect of SOA from masked priming.

The issue of bilingual phonological access remains unclear for bilinguals with cross-script language systems, which is especially true when the time course of phonological activation is involved. To investigate the time course of cross-script phonological activation, the present study asked Chinese-English bilinguals to complete a word naming task that was conducted in a forward-masked phonological priming paradigm in three stimulus onset asynchrony (SOA) conditions. By comparing the interlingual and intralingual phonological priming effects in a within-subjects design, we found that (a) target naming in Chinese and English was facilitated by a phonologically similar English or Chinese prime in the three SOA conditions (43 ms, 75 ms, and 150 ms) and the facilitation effect of the prime reached the peak when the pronunciation of the prime-target pair most resembled each other and (b) manipulation of the SOAs affected both the naming latencies of target words and the sizes of the phonological priming effect. In particular, naming latencies in each prime-target type displayed an increasing tendency as the SOA prolonged. Moreover, despite the varied sizes of the priming effect in the three SOA conditions, we found a consistent pattern that the priming effects in two interlingual conditions resembled their respective intralingual conditions along the time course. Taken together, these findings provide strong support for an integrated phonological representation of bilinguals and further extend the language nonselective access hypothesis to language pairs with very different orthographic systems. Implications for the manipulation of the SOAs in the masked priming paradigm are also discussed. (PsycInfo Database Record (c) 2021 APA, all rights reserved).