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J Mater Sci Mater Med ; 25(1): 217-27, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-24072390

RESUMO

The aim of this study was to explore the potential for a better recovery outcome for the Achilles tendon at an early healing stage when a mixed biomaterial-tenocyte injection is used. The experimental animals underwent single limb Achilles tendon transection followed by suturing repair. A solution of either hyaluronic acid with or without tenocytes or normal saline was randomly chosen to be injected around the injury site after surgery. To obtain the comprehensive recovery condition of the rats on different management protocols, the animals were evaluated histologically, mechanically, and functionally. A significant difference in the recovery condition was found in the injured tendon injected with the hyaluronic acid solution with tenocytes compared with the other groups. Tendon stiffness and the locomotion abilities of the rats with healing Achilles tendons were improved in the hyaluronic acid with tenocyte transplantation group. The acceleration of the inflammatory phase in rats with the hyaluronic acid with tenocyte injections might be the major reason for the better functional outcomes.


Assuntos
Tendão do Calcâneo/lesões , Transplante de Células , Ácido Hialurônico/administração & dosagem , Traumatismos dos Tendões/terapia , Tendão do Calcâneo/citologia , Animais , Fenômenos Biomecânicos , Modelos Animais de Doenças , Marcha , Masculino , Teste de Materiais , Ratos , Ratos Sprague-Dawley , Ruptura/patologia , Ruptura/fisiopatologia , Ruptura/terapia , Traumatismos dos Tendões/patologia , Traumatismos dos Tendões/fisiopatologia , Cicatrização/efeitos dos fármacos
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