Detection and analysis of apoptosis- and autophagy-related miRNAs of mouse vascular endothelial cells in chronic intermittent hypoxia model.

Endothelial dysfunction is the main pathogenic mechanism of cardiovascular complications induced by obstructive sleep apnea/hyponea syndrome (OSAHS). Chronic intermittent hypoxia (CIH) is the primary factor of OSAHS-associated endothelial dysfunction. The hypoxia inducible factor (HIF) pathway regulates the expression of downstream target genes and mediates cell apoptosis caused by CIH-induced endothelial injury. miRNAs play extensive and important negative regulatory roles in this process at the post-transcriptional level. However, the regulatory mechanism of miRNAs in CIH tissue models remains unclear. The present study established a mouse aortic endothelial cell model of CIH in an attempt to screen out specific miRNAs by using miRNA chip analysis. It was found that 14 miRNAs were differentially expressed. Of them, 6 were significantly different and verified by quantitative real-time PCR (Q-PCR), of which four were up-regulated and two were down-regulated markedly. To gain an unbiased global perspective on subsequent regulation by altered miRNAs, we established signaling networks by GO to predict the target genes of the 6 miRNAs. It was found that the 6 identified miRNAs were apoptosis- or autophagy-related target genes. Down-regulation of miR-193 inhibits CIH induced endothelial injury and apoptosis- or autophagy-related protein expression. In conclusion, our results showed that CIH could induce differential expression of miRNAs, and alteration in the miRNA expression pattern was associated with the expression of apoptosis- or autophagy-related genes.

WITHDRAWN: Detection and analysis of apoptosis- and autophagy-related miRNAs of vascular endothelial cells in a mouse chronic intermittent hypoxia model.

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Analysis of articles and citations of Chinese Journal of Pediatrics from 1950 to 2009 / 中华儿科杂志

<p><b>OBJECTIVE</b>To explore the articles, authors and citations of the articles published in Chinese Journal of Pediatrics, and have a clear view of the characteristics of this journal in its different development stages.</p><p><b>METHOD</b>Bibliometric methods were used to analyze the published articles, cooperation, regional distribution, core authors, corresponding authors and high-quantities of publication institutes, and also to calculate the number of citations per paper, types of citations, language-based citation number, Price index, self-cited rate and the distribution of journals based on citations.</p><p><b>RESULT</b>Totally 5534 academic articles were published during the 60 years, of which the number of articles written by more than one author was 4669 (80.71%), with a degree of collaboration as 3.87, and a rate of collaboration as 84.37%. The number of articles by a single author was 865 (19.29%). As for the regions from where the papers were submitted, the top one was Beijing, which had 1495 articles published (27.01%). The top 15 institutes in number of articles had published 2254 articles (40.73%). The average citation rate was 84.15%, and the number of citations was 48 854. The number of citations per paper was 10.06, the Price index and self-cited rate were 55.57% and 6.12%, respectively. The number of citations from foreign language literature was 35 781 (69.1%). The citation number of journals was 43 266 (84.5%), which is markedly higher than the citations of books and others.</p><p><b>CONCLUSION</b>Chinese Journal of Pediatrics has a wide distribution of authors and a high cooperative rate. This journal has a group of high-level core authors since founded in 1950, and it shows an adequate ability of absorbing and using scientific information. The articles published in this journal not only objectively reflected the distribution of the research powers, but also the development status of pediatrics in our country.</p>

An analysis of articles published in Chinese Journal of Pediatrics from 1996 to 2005 / 中华儿科杂志

<p><b>OBJECTIVE</b>To explore, on the basis of principles of bibliometrics, the distribution of the authors of the articles published in Chinese Journal of Pediatrics, and the types of the institutions and the different regions from where the manuscripts were submitted in order to make a clear view of the characteristics and the status of cooperations in pediatric research work; to ascertain, among them, the core authors, core institutes and core regions; and to analyze the significance of corresponding authors, a new regulation adopted by this Journal in recent years, and to explore, furthermore, the funding status of the studies.</p><p><b>METHOD</b>Based on the information drawn from Chinese Medical Current Content (CMCC), bibliometric method was used to analyze the publications in Chinese Journal of Pediatrics and their authorship during the period from 1996 to 2005.</p><p><b>RESULT</b>Totally 3337 academic articles were published during the ten years; of which the number of articles written by more than one authors was 2951, accounting for 88.43 %, with a degree of collaboration as 4.12. The number of articles by a single author was 386 (11.57%). A total of 234 core authors contributed to 1031 research papers published (30.90% of all). As for the regions from where the papers were submitted, the top one was Beijing, which had 968 articles published (29% of all). And for the institutes, the number of the papers from the hospitals affiliated to medical schools was 2095 (62.78% of all), ranked the first. The second was research institutes which had 261 articles published in the Journal (7.82%), and 68 articles were from colleges and universities which ranked the third (2.03%). The top 10 institutes in number of papers had published 1273 articles (38.15% of all). The articles, from research projects funded by certain grants published in this Journal increased almost every year, from 7.44% of 1996 to 25.82% of 2005', which reflected timely and objectively a growing tendency in pediatric research and that funded research projects by certain garnts could be an important support to the publication of academic papers. The corresponding authorship as a signature regulation was introduced by this Journal in 1999, which played a positive role in pushing the leading work of key authors in construction of research groups. There were 2243 articles of pediatric clinical studies, (67.22%) and 1094 of basic research (32.78%).</p><p><b>CONCLUSION</b>Chinese Journal of Pediatrics had a wide distribution of authors and a high cooperative rate. This Journal had a group of core authors who were strong in academy, active in research and productive in papers, and had a strong positive impact on this Journal. But it was also revealed that the research powers in the field of pediatric study were not evenly distributed. The guideline adopted by and for this Journal was clear and correct. The articles published in this Journal not only objectively reflected the distribution of the research powers and the latest achievements in pediatric study over the country, but also had its focus, which played a certain leading role in pediatric research.</p>