Long-term evolution of cytophagic histiocytic panniculitis.

BACKGROUND: Cytophagic histiocytic panniculitis is a disorder manifested by multiple subcutaneous nodules, characterized by lobular panniculitis, and occasionally accompanied by severe systemic manifestations, which require an aggressive medical approach. Several case reports with a good response to immunosuppressive therapy in the acute phase can be found in the literature. OBJECTIVE AND CONCLUSION: Nevertheless, the long-term evolution of this entity has not been described yet, nor have precise recommendations regarding the most adequate posology and duration of therapy. We report the result of switching from a long-term cyclosporine therapy to tacrolimus in a patient with a severe form of cytophagic histiocytic panniculitis.

Anetodermia primaria / Primary anetoderma

Mujer de 28 años de edad que presenta máculas y pápulas de aspecto atrófico, asintomáticas, localizadas en tronco y extremidades superiores de 8 años de evolución. Se realizó escisión-biopsia de una de las lesiones que reveló mediante tinción de orceína una disminución y fragmentación de las fibras elásticas en dermis reticular. Se descartaron posibles causas y asociaciones diagnosticándose de anetodermia primaria. Destacamos este caso por ser poco común en la clínica y proponemos la elaboración de un protocolo de actuación ante una anetodermia

A 28 years old woman who complains because the presence of atrophic macules and papules appearing progresivelly in the last 8 years is reported. The lesions were asymptomatic and they were located in the trunk and arms. An excisional biopsy was performed. Ordein stain revealed an important decrease and destruction of the elastical tissue in reticular dermis. Posible related causes and associated conditions were excluded and the diagnose of a primary anetoderma were stablished. We like to emphasize this case report because it is an uncommon disease and at the same time we propose a medical protocol for its study

[Cutaneous necrosis due to interferon alpha in a patient with melanoma]. / Necrosis cutánea por interferón alfa en paciente con melanoma.

We present the case of a 55-year-old male with melanoma in the right retroauricular region who had cutaneous necrosis only in one of the injection sites after adjuvant treatment with interferon (IFN alpha 2b) according to the Kirkwood proposed regime. Appearance of cutaneous necrosis is a rare condition that has been described in patients treated with different types of IFN.

Necrosis cutánea por interferón alfa en paciente con melanoma / Cutaneous necrosis due to interferon alpha in a patient with melanoma

Presentamos el caso de un varón de 55 años con un melanoma en la región retroauricular derecha que después de un tratamiento quirúrgico y adyuvante con interferón (IFN alfa 2b) según la pauta propuesta por Kirkwood presentó, en el último mes de tratamiento, una necrosis cutánea sólo en uno de los sitios de inyección. La aparición de necrosis cutánea es una situación rara que se ha descrito en pacientes tratados con distintos tipos de IFN

We present the case of a 55-year-old male with melanoma in the right retroauricular region who had cutaneous necrosis only in one of the injection sites after adjuvant treatment with interferon (IFN alpha 2b) according to the Kirkwood proposed regime. Appearance of cutaneous necrosis is a rare condition that has been described in patients treated with different types of IFN

Amputation neuromas after neck surgery.

Traumatic or amputation neuromas are benign tumours formed by a proliferation of Schwann cells, axons and connective tissue elements. They are secondary to the partial or total section of a nerve pathway due to an accidental or surgical trauma. They can form at any site and affect any type of nerve. The presence of amputation neuromas is very frequent in major surgery but rare in simple excisions of skin tumours. We report two cases with neuroma localized in the neck, one after lymph node dissection for melanoma metastasis and the other after excision of a cutaneous melanoma with 3-cm margin on lateral neck. In both cases, the presence of the neuroma mandated a surgical excision to rule out a possible recurrence of melanoma.

Pápulas faciales en un trasplantado renal

No disponible

Leishmaniasis cutánea crónica: respuesta a n-metil glucamina intralesional tras fracaso con paramomicina tópica / Chronic cutaneous leishmaniasis: response to intralesional n-metil glucamine after failure with topical paramomycin

La leishmaniasis cutánea es una de las causas más importantes de úlcera cutánea crónica en el litoral mediterráneo. Presentamos el caso de una mujer de 87 años que consulta por la aparición de una lesión en frente de 8 meses de evolución clínicamente sugerente de eccema que en el estudio histológico demostró que se trataba de una leishmaniasis. Se trató sin éxito primero con rifampicina y posteriormente con paramomicina tópica al 15%, por lo que se aplicó n-metil glucamina intralesional, obteniéndose la curación a los 2 meses. El tratamiento de elección de la leishmaniasis cutánea son los antimoniales pentavalentes (vía parenteral o intralesional). Se discute la eficacia del tratamiento tópico con paromomicina al 15% (AU)