[Cytologic classification of precancer and cancer of the endometrium and esophagus and of malignant lymphomas]. / Tsitologicheskie klassifikatsii predraka i raka éndometriia, pishchevoda, zlokachestvennykh limfom.

The paper discusses cytological classifications of precancer and cancer of the endometrium, esophagus and malignant lymphomas presented by cytologists from five Soviet research institutes of oncology. The classifications were based on the data of 4400 cases in conformity with WHO histologic classifications.

[Cytological characteristics of aspirates from cancer of the prostate]. / Tsitologicheskaia kharakteristika punktata raka predstatel'noi zhelezy.

The results of a macro- and microscopic study of aspirate obtained from prostatic cancer patients in 253 needle biopsies are presented. In well-differentiated cancer, it was abundant, blood-stained, with large layers of the prostatic epithelium and insignificant atypia and polymorphism of tumor cells. Aspirate from moderately-differentiated tumors was scarce, generally blood-free, with small layers of the epithelium and considerable levels of isolated moderately polymorphous cells. In poorly-differentiated tumors, aspirate was also abundant but usually blood-free and contained isolated sharply polymorphous tumor cells.

[Oncornavirus activation and accumulation in cell cultures under the influence of hormones]. / Izuchenie aktivatsii i nakopleniia onkornavirusa v kul'turakh kletok pod vliianiem nekotoryk gormonov.

Sex hormones (testosterone, estradiol) and thyroxine would activate irregularly the production of the specific group antigen (GS-antigen) of avian ribodesoxyviruses in the culture of "normal" chick embryonal cells (CEC, phenotype C/O, GS-). The mentioned hormones as well as hydrocortisone and insulin would not prevent the Rous sarcoma virus (RSV) infecting of CEC, render no essential action on the accumulation of RSV in the infected CEC culture, and failed to activate the formation of mature RSV in virogenic cultures of rat (XC, R--B77) and mice cells (DBA--B77).

[Effect of thyroxine, insulin and cholesterol on the amount of cyclic adenosine monophosphate in normal and oncornavirus infected cells]. / Vliianie tiroksina, insulina i kholesterina na soderzhanie tsiklicheskogo adenozinmonofosfata v normal'mykh i zarazhennykh onkornavirusom kletkakh.

The intracellular concentration of cyclic AMP in normal cells and in cells infected with the Rous sarcoma virus (chicken fibroblasts) was determined by the method of saturation analysis (method of concurrent binding with protein). Thyroxine (2 mcg/ml) increased the level of cyclic AMP both in normal and infected cells, insulin (2 mcg/ml) decreased the concentration of cyclic AMP in infected cells, but cholesterol (5 mcg/ml) exerted no effect on this parameter in infected cells. The data are discussed from the point of view of a possible influence of hormones on the cholesterol accumulation in cells and on the adenylatecyclase activity in cell membranes.

[Transforming action of the total RNA preparations isolated from Rous virus-induced sarcomas]. / O transformiruiushchem deistvii preparatov summarnoi RNK, vydelennykh iz sarkom indutsirovannykh virusom Rausa.

The authors compared the effect of RNA substances isolated from chick sarcomas producing Rous virus and hamster sarcomas not producing the virus. In both species of animals the tumors were induced by the same Rous virus strain (Carr-Zilber). The treatment of embryonal cells cultures both of the chick and hamster with RNA preparations resulted in the morphological transformation. The action of RNA-s would reduce considerably or eliminated totally the effect, while DNA-s failed to influence the activity of the preparations under study. Embryonal cells culture in hamsters proved to be more sensitive to RNA action than chick cells.