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Objective To explore the correlation between personality characteristics and psychologi-cal craving in methamphetamine addicts,and to provide theoretical basis and empirical experience for the prevention of relapse. Methods Cattell 16 personality factor questionnaire and drug craving questionnaire were administered to 315 cases of methamphetamine addicts,to understand the personality factor of metham-phetamine addicts,psychological craving for drugs in the period of detoxification. Spearman correlation analy-sis was used to explore the relationship between personality traits and psychological craving. Results Intelli-gence(1. 13±2. 86),stability(4. 57±1. 42),perseverance(3. 39±2. 20),independence (4. 16±1. 39)and self-discipline (4. 81±1. 78)of methamphetamine addicts were significantly lower than the norm (P<0. 01), while the strength(7. 01±1. 96),bravity(6. 83±1. 54),sensitivity(6. 18±1. 81),suspicion(6. 31±2. 08), fantasy(8. 98±1. 32),anxiety(6. 33±2. 00) and tension(6. 21±2. 14) were significantly higher than the norm (P<0. 01). The total average score of craving for methamphetamine addicts was (3. 36±1. 85). The correlation between the total average score of craving and intelligence (r=-0. 201,P<0. 01),stability (r=-0. 275,P<0. 01),constant (r=-0. 184,P<0. 05),dominance (r=0. 269,P<0. 01),bravity ( r=0. 210,P< 0. 01),anxiety (r=0. 259,P<0. 01),independent (r=-0. 254,P<0. 01) were significant. Conclusion -Methamphetamine addicts are significantly different from ordinary people's personality traits, physiological withdrawal period still exists a certain degree of psychological craving for drugs. The stability of personality has a negative predictive effect on craving,while aggressiveness has a positive predictive effect on craving.
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Objective To study the effect of glutamate on the expression of vascular endothelial growth factor (VEGF) mRNA and protein in cultured rat astrocytes. Methods Cultured rat astrocytes were randomly divided into 6 groups: control group (C), glutamate group (G), QA group (Q), DCG-IV group (D), L-AP4 group (L) and glutanmte-FMCPG gronp (G+M). Cells were cultured under nomoxic condition (95% air, 5% CO2). RT-PCR and ELISA methods were used to detect the expression of VEGF mRNA and protein in cultured astrocytes, respectively. G+ M group was preincubated with lmM MCPG for 30 min prior to the stimulation with glutamate. There were 7 time points at 0,4,8,12,16,24 and 48 h in each group except G+M group. Results The expression of VEGF mRNA and protein did not differ significantly among D group, L group and C group. Different from that in C group, the expression of VEGF mRNA and protein could be enhanced both in a dose-dependent and time-dependent manner in G group and Q group. Meanwhile, the enhanced expression of VEGF mRNA and protein in G group was completely suppressed by MCPG after 24 h. Conclusion Glutamate can increase the expression of VEGF mRNA and protein in cultured astrocytes, which may be due to the activation of group I metabotropic glutamate receptors in astrocytes.
