Characteristics and research status among clinical trials in cardio-oncology by bibliometric and visualized analysis.

BACKGROUND: We aim to establish the characteristics of published cardio-oncology research of clinical trials by bibliometric analysis and to talk about the prospects and difficulties facing the development of cardio-oncology. METHODS: Search of data related to clinical trials in cardiac oncology from 1990 to 2022 from the Web of Science core collection. Using CiteSpace to perform co-citation analysis of authors, countries (regions) and institutions, journals and cited journals, cited authors and cited literature, and keywords. RESULTS: Of the 607 clinical trial studies, the number of papers published per year has increased over time. The regions with the greatest influence were North America (especially the United States) and Europe. Multicenter research has always been the focus of cardio-oncology research, but cross-regional cooperation was still lacking. Myocardial toxicity caused by anthracyclines has received the earliest attention and has been studied for the longest time. Meanwhile, the efficacy and cardiotoxicity of new anticancer drugs always came into focus, but at a slow pace. Few studies on myocardial toxicity were related to the treatment of tumors except breast cancer. Risk factors, heart disease, adverse outcomes, follow-up, and intervention protection were the major hotspots revealed by co-citation cluster. CONCLUSIONS: There is great potential for the development of clinical trials in cardio-oncology, especially in multicenter cooperation across different regions. Expansion of tumor types, myocardial toxicity of different drugs, and effective interventions in the research direction and design of clinical trials are necessary.

Risk Factors of Functional Dyspepsia Patients With Anxiety / 胃肠病学

Background: Patients with functional dyspepsia (FD) often complicated with anxiety. Recognizing effectively the risk factors of anxiety is helpful for the precise treatment with anti-anxiety drug, which can improve the prognosis of patients. Aims: To explore the clinical characteristics and risk factors of FD patients with anxiety. Methods: A total of 295 FD patients from June 2014 to September 2014 at the Second Xiangya Hospital of Central South University were enrolled. Hamilton Anxiety Rating Scale was used to evaluate the anxiety in FD patients. Risk factors of anxiety in FD patients were analyzed. Results: In this study, the incidence of anxiety was 8.1% (24/295) in FD patients. Univariate analysis showed that age, disease duration, marriage status, psychosis history and history of administration of psychotropic drugs were related to the anxiety in FD patients (P<0.05). Multivariate analysis showed that disease duration, marriage status and psychosis history were the risk factors for anxiety in FD patients (P<0.05). Conclusions: Long disease duration, incomplete marriage, and psychosis history are the risk factors for anxiety in FD patients, routine anxiety screening should be carried out in these patients.

Risk factors of depression in patients with functional dyspepsia / 中国医师杂志

Objective To explore the risk factors of depression in patients with functional dyspepsia.Methods From July 2014 to September 2014, a total of 295 patients was diagnosed of functional dyspepsia (FD).All of them were evaluated with the 17-item Hamilton Depression Rating Scale (HAMD-17).They were divided into two groups: FD with depression and FD without depression.Socio-demographic and clinical features were collected and analyzed.Logistic regression analysis was used to detect risk factors of depression in FD patients.Results In our studies, 20.0％ (59/295) of FD patients were diagnosed as depression.Risk factors for depression were age, disease duration, and marriage in univariate analysis, and marriage and disease duration in multivariate analysis.FD patients with moderate to severe depression had a longer duration of disease and more sessions of gastroscopy than those with mild depression.Conclusions Prevalence of depression is higher in FD patients with incomplete marriage and long disease duration, routine depression screening should be carried out for these patients.