[An evaluation of the protection by mono-oxygenase enzyme-inducing pharmacological agents against pesticides by the lethality indices]. / Otsenka zashchity farmakologicheskimi sredstvami, indutsiruiushchimi monooksigenaznye fermenty, ot pestitsidov po pokazateliam letal'nosti.

Experiments with non-inbred mice established that there was a direct correlation between the defence index (DI) of monooxygenase enzyme (ME) inductors and the coefficient of variation of LD50 which were used to determine the DI of toxicants, which reflected the LD16-LD84 interval. This interval should be borne in mind while evaluating the effect of pharmacological agents exerting an inducing action of P-450-dependent hepatic monooxygenases, which allows the formula to be constructed.

[Effect of inducers and inhibitors of mixed function oxidases on body resistance to endotoxins of gram-negative bacteria]. / Vliianie induktorov i ingibitorov oksidaz smeshannoi funktsii na rezistentnost' organizma k éndotoksinam gramotritsatel'nykh bakterii.

Experimental typhoid intoxication in white mice leads to the inhibition of microsomal oxidation in the liver, which is manifested by the prolongation of hexenal-induced sleep and a decrease in the toxic action of parathion. Phenobarbital, capable of inducing oxidases with mixed function (OMF), enhances the process of the detoxification of endotoxin injected into the animals, which is manifested by the increase of its LD50. Soluble levomycetin succinate, widely used for the treatment of typhoid-paratyphoid infections, is a powerful inhibitor of OMF (as shown by the hexenal test). Benzonal, the analog of phenobarbital, removes the inhibitory effect of the antibiotic. Experimental studies carried out in the course of this investigation make it possible to substantiate the clinical trial of these preparations (OMF inducers) used in the complex therapy of typhoid-paratyphoid infections for the stimulation of natural detoxification mechanisms of the body. Benzonal is the preparation of choice for use in clinical practice.

[Effect of benzonal on the liver mono-oxygenase system of laboratory animals]. / Vliianie benzonala na monooksigenaznuiu sistemu pecheni laboratornykh zhivotnykh.

The data are provided on benzonal as having the properties of the monoxygenase system inducer, evidenced by the shortening of hexenal sleep, increase of the intensity of the epr-signal of cytochrome P-450, activation of lipid peroxidation, carboxylesterase and arylesterase in the liver. The properties of benzonal described can be made use of for increasing the body resistance to the toxic action of xenobiotics.

[Effect of benzonal on the resistance of animals to the action of organophosphorus and carbamic compounds]. / Vliianie benzonala na ustoichivost' zhivotnykh k deistviiu fosfororganicheskikh i karbaminovykh soedinenii.

The inductor of microsomal enzymes, benzonal (20 mg/kg) produces an overt preventive and treatment-preventive action in acute and subacute poisoning with organophosphorus (DDVP, parathion, TEPP, chlorophos) and carbamic (pirimor, sevin) compounds. As regards the efficacy benzonal is not inferior to phenobarbital (14 mg/kg). Pretreatment with benzonal averts the development of the neuromuscular blockade and normalizes spontaneous activity of the myoneural synapse of rats and cats poisoned with pirimor and parathion.