[Long-term atrovent treatment of chronic obstructive bronchitis]. / Dlitel'noe lechenie atroventom pri khronicheskom obstruktivnom bronkhite.

AIM: The study of effects of long-term ipratropium bromide on the course of chronic obstructive bronchitis. MATERIALS AND METHODS: A 3-month atrovent monotherapy (3-6 doses daily) was performed in 19 patients with verified chronic obstructive bronchitis of moderate severity. Monitoring consisted of symptoms registration, pickflowmetry (two times a day), external respiration measurements. RESULTS: Atropen produced a positive trend in all the clinical symptoms, course of viral infections, exercise tolerance, bronchial permeability, respiratory capacity. The highest atrovent efficacy was recorded in patients with chronic bronchitis of smokers and chronic bronchitis in tracheobronchial diskinesia. No side effects were observed. CONCLUSION: Basic atrovent monotherapy modifies the course of chronic obstructive bronchitis and can be recommended for secondary prophylaxis of this disease.

[Functional activity of precursor cells of granulo-monocytopoiesis and stromal precursor cells in acute suppurative-destructive lung diseases]. / Funktsional'naia aktivnost' kletok-predshestvennikov granulomonotsitopoéza i stromal'nykh kletok-predshestvennikov pri ostrykh gnoino-destruktivnykh zabolevaniiakh legkikh.

Under study was functional activity of stromal (fibroblast) and granulo-monocytic cells-precursors in bone marrow cultures of 32 patients with acute pyodestructive diseases of the lungs. The disturbance of functional activity of cells-precursors of granulo-monocytopoiesis and stromal cells-precursors responsible for regulation of hemopoiesis was established which makes for the development of leukemoid reactions and anemia in patients with acute pyo-destructive diseases of the lungs.

[Changes in the characteristics of human granulo- and monocytopoiesis and the activity of stromal precursor cells in acute hypobaric hypoxia]. / Izmenenie kharakteristik granulo- i monotsitopoéza i aktivnosti stromal'nykh kletok-predshestvennikov u cheloveka pri ostroi gipobaricheskoi gipoksii.

10 healthy men underwent a 48 hour acute hypobaric hypoxia in the "Tabai" climate chamber imitating conditions of an altitude of 4.00 m. above s.l. The "ascent" and "descent" took 30 minutes each. Blood and bone marrow samples were taken before entering the chamber and immediately after leaving it. A decrease in colony-forming capacity of granulo- and monocyte and fibroblast precursors was shown, along with an increase in functional activity of circulating monocytes and monocyte precursors in bone marrow. A possible role of changes in granulo- and monocytopoiesis and in stromal cells is discussed in relation to the increased morbidity and decreased cicatricial and bone tissue reparation in the mountains.