RESUMO
A single total body cooling was found to cause a more distinct alteration in carbohydrate metabolism in lung tissue of male rats as compared with female rats. These metabolic alterations were less distinct in castrated males. Preadministration of one of the sex hormones (testosterone, estradiol or progesterone) into the castrated males led to normalisation of carbohydrate metabolism in cooling; among the sex steroids estrogen was the most effective.
Assuntos
Metabolismo dos Carboidratos , Temperatura Baixa , Estradiol/fisiologia , Pulmão/metabolismo , Testosterona/fisiologia , Adaptação Fisiológica , Animais , Castração , Estro , Feminino , Pulmão/enzimologia , Masculino , Oxirredutases/metabolismo , RatosRESUMO
It has been demonstrated in experiments on rats with an ischemized hind limb that sodium hydroxybutyrate promoted activation of glucose-6-phosphate dehydrogenase of the pentosophosphate cycle, prevented the changes in the content of lactic acid and activity of lactate dehydrogenase in the ischemized muscle, interfered with the development of metabolic acidosis during devascularization of the ischemized limb.