[Pathogenic properties of fungi Fusarium genus isolated from patients with atopic dermatitis].

AIM: Study of adhesive activity and growth speed of fungi Fusarium genus isolated from the surface of cutaneous covering in patients with atopic dermatitis (AD). MATERIALS AND METHODS: Clinical and museum F. oxysporum, F. solani strains were used in the study. Seeding was carried out into agarized Czapek and Sabouraud medium. The cultures were studied for9 days at 30 +/- 2 degrees C, adhesive properties of fungi were determined by using model based on nitrocellulose film (S.A. Lisovskaya et al., 2006). RESULTS: The studies carried out showed statistically significant differences in adhesive properties and intergrowth intensity of various Fusarium spp. Adhesion level of F. solani microconidia was almost 2.5 times higher compared with F. oxysporum. Formation of the first germ tube by F. solani microconidia was noted during the first 10 hours whereas by F. oxysporum--only at day 2. CONCLUSION: The data obtained confirm species differences of Fusarium spp. pathogenic properties that emphasize the importance of species identification of fungi.

[Protective effect of 2-aminobenzimidazole during hyperbaric oxygenation and the state of cerebral nitrogen metabolism]. / Zashchitnoe deistvie 2-aminobenzimidazola pri giperbaricheskoi oksigenatsii i sostoianie azotistogo obmena mozga.

The protective effect of 2-aminobenzimidazole (2-ABI) was studied on white rats exposed to oxygen at 4 and 6 ata. During an exposure to oxygen at 6 ata injections of 2-ABI (in 1 ml saline at a dose of 5 mg per 100 g body weight) 10 min prior to the exposure delayed significantly (3 to 4 times) the time when convulsions began and assured 100% survival after the exposure (30 days). During an exposure to 4 ata (prolonged exposure) the injections did not delay convulsions but alleviated them and provided 100% survival after the exposure (30 days). Variations in the content of ammonia, glutamine, glutamic and aspartic acids and GAMA in the brain of treated and untreated animals were examined. By the beginning of convulsions the content of dicarboxylic amino acids and GABA remained unchanged in the treated animals. The level of ammonia and glutamine was not controlled by 2-ABI. After the exposure 2-ABI accelerated the return of metabolic parameters to the normal.