Use of rhBMP-2/ß-TCP for Interpositional Vertical Grafting Augmentation: 5.5-Year Follow-up Clinically and Histologically.

PURPOSE: This case report documented long-term results using rh-BMP-2/ß-tricalcium phosphate (TCP) for vertical grafting augmentation. MATERIALS AND METHODS: A 58-year-old patient with extreme atrophy of the left posterior mandible was treated with rh-BMP-2/ß-TCP for vertical bone augmentation. At the time of implant placement, bone biopsy was performed for histological evaluation. RESULTS: Seven months after surgery, CT scan demonstrated approximately 8 mm of bone gain height. The histological results revealed a newly formed vital bone tissue, predominantly lamellar with variable density. Remaining bone ceramic surrounded by newly formed bone tissue or connective tissue was observed. The bone levels remained unchanged during the entire period treatment (5.5 years). CONCLUSION: This technique has demonstrated a potential for reconstruction of atrophic sites when vertical bone gain is desirable. Moreover, the bone gain has shown long-term maintenance without resorption. Future long-term prospective clinical trials are needed to confirm these findings.

Recombinant human bone morphogenetic protein type 2 in the reconstruction of atrophic maxilla: Case report with long-term follow-up.

Autologous bone is reported by scientific literature as the gold standard for the replacement of the bone loss in maxillary atrophic area. Notwithstanding, this grafting type shows several disadvantages as: The procedure morbidity, limited size of the graft and longer recovering time. Recombinant human bone morphogenetic protein type 2 (rhBMP-2) has been used as bone substitute for the reconstruction of large bone defects. The aim of this case was to report a clinical case exhibiting the reconstruction of the atrophic maxilla through using rhBMP-2 as grafting material associated with absorbable collagen sponge (ACS). At 8 months of following-up, osseointegrated implants were placed. After 2 years and 5 months of following-up, it could be observed an appropriate aesthetical and functional rehabilitation.

O uso de rhBMP-2/beta-TCP para técnica de enxerto vertical interposicional: relato de caso com quatro anos de acompanhamento / The use of rhBMP-2/beta-TCP for interpositional vertical graft technique: a case report with 4 years of follow-up

A reconstrução óssea de mandíbulas atróficas para o posicionamento de implantes dentários ainda é um grande desafio na Implantodontia atual. Para um ganho ósseo vertical, a técnica de enxerto interposicional com a utilização de enxerto de osso autógeno, ou algum substituto ósseo, apresentou excelentes resultados. Neste relato de caso, um paciente com 58 anos de idade e ausências entre os elementos 34 e 38 apresentava 3 mm de altura entre a crista óssea e o nervo alveolar inferior pelo exame de TCFC, impossibilitando o posicionamento de implantes sem enxertos prévios para ganho em altura e espessura. Com a utilização de rhBMP-2 como osteoindutor, associada ao beta-TCP como osteocondutor, foi possível regenerar o local com pouca morbidade e com ganho ósseo satisfatório (8 mm) para o posicionamento dos implantes. Após sete meses da consolidação do enxerto, implantes de diâmetro estreito (3,3 mm) foram posicionados e o paciente foi reabilitado sem complicações ou intercorrências durante todo o tratamento. Os autores sugerem que essa técnica tem um grande potencial para reconstruções de regiões atróficas, com um excelente ganho ósseo vertical, pouca morbidade e grande previsibilidade de resultados.

Bone reconstruction of atrophic mandibles for correct implant positioning is a great challenge on contemporary dentistry. Also, the interpositional graft technique using autogenous or bone substitute materials for vertical augmentation has presented excellent outcomes. This case report presents a 58 years-old patient with tooth loss from 34 to 38 regions having 3 mm from the bone crest to the inferior alveolar nerve canal according to the CBCT exam preventing implant placement without previous grafts for horizontal and vertical augmentation. With the aid of rhBMP-2 (osteoinductive) and beta-TCP (osteoconductive) materials it was possible to regenerate the area with less morbidity and satisfactory bone gain (8 mm) for implant placement. Seven months after graft healing narrow diameter implants (3.3 mm) were positioned and the patient rehabilitated without complications during the course of treatment. The authors suggest that this technique has a great potential for reconstruction of atrophic sites with excellent vertical bone gain, less morbidity, and great outcome predictability.