[Quantitative histoenzymatic analysis of the hypothalamic neurosecretory system in rat ontogeny]. / Kolichestvennyi gistofermentnyi analiz neirosekretornoi sistemy gipotalamusa v ontogeneze krys.

In experiments on 6 and 16 days old rats cytophotometric studies have been made of histochemical reactions for succinate, lactate and glutamate dehydrogenases, alpha-glycerophosphate dehydrogenase and glucose-6-phosphate dehydrogenase in the supraoptic nucleus, paraventricular hypothalamic nucleus and the posterior hypophysis. It was found that heterochronous development of the neurones in the supraoptic and paraventricular nuclei, as well as the development of their axons in the posterior hypothalamus depend on the rate of maturation of the enzymic systems in postnatal life. In consolidation of the unique structure of the hypothalamic neurosecretory system, the key role is played by afferent influences, succinic dehydrogenase being involved into their realization. The data obtained indicate the importance of heterochronous development of the enzymic activities in the formation of bifunctional properties of neurosecretory hypothalamic neurones and reveal the primary development of neurotransmittery function as compared to the excretory one.

[Role of conditionally pathogenic microbes in the development of experimental destructive pneumonia]. / Rol'uslovno-patogennykh mikrobov v razvitii éksperimental'noi destruktivnoi pnevmonii.

Experiments on 32 puppies with a preliminary decrease of immunologic resistance have demonstrated the possibility of the development of purulent destructive pneumonia under the effect of opportunistic microorganisms, such as Proteins, Escherichia coli, Pseudomonas aeruginosa. Histoenzymatic studies of a pathologically changed lung tissue have disclosed appreciable microcirculatory disorders and destruction of the bronchioli and thus promoted the unraveling of the pathogenesis of pulmonary destructive foci.

[Features of the morphofunctional response of Peyer's patches in rats during the course of traumatic shock and the early post-shock period]. / Osobennosti morfofunktsional'noi reaktsii peierovykh bliashek krys v dinamike travmaticheskogo shoka i rannego posleshokovogo perioda.

The reaction of Peyer's patches to trauma manifests in: 1) vascular changes; 2) primary or stressor cells shifts recordable in traumatic shock, characterized by depletion of patch follicles by minor lymphocytes; 3) secondary changes associated with the onset of reparative processes; 4) the increased macrophagal activity detectable during the entire period of the traumatic shock and in the early post-shock period. It is suggested that changes seen may be due to endotoxin that penetrates from the intestine.