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1.
IEEE Trans Biomed Circuits Syst ; 16(6): 1375-1386, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-36315548

RESUMO

As dendrites are essential parts of neurons, they are crucial factors for neuronal activities to follow multiple timescale dynamics, which ultimately affect information processing and cognition. However, in the common SNN (Spiking Neural Networks), the hardware-based LIF (Leaky Integrate-and-Fire) circuit only simulates the single timescale dynamic of soma without relating dendritic morphologies, which may limit the capability of simulating neurons to process information. This study proposes the dendritic fractal model mainly for quantifying dendritic morphological effects containing branch and length. To realize this model, We design multiple analog fractional-order circuits (AFCs) which match their extended structures and parameters with the dendritic features. Then introducing AFC into FLIF (Fractional Leaky Integrate-and-Fire) neuron circuits can demonstrate the same multiple timescale dynamics of spiking patterns as biological neurons, including spiking adaptation, inter-spike variability with power-law distribution, first-spike latency, and intrinsic memory. By contrast, it further enhances the degree of mimicry of neuron models and provides a more accurate model for understanding neural computation and cognition mechanisms.


Assuntos
Fractais , Modelos Neurológicos , Potenciais de Ação/fisiologia , Neurônios/fisiologia , Redes Neurais de Computação
2.
Front Neurosci ; 16: 976249, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35968371

RESUMO

Patellofemoral pain syndrome (PFPS) is a common, yet misunderstood, knee pathology. Early accurate diagnosis can help avoid the deterioration of the disease. However, the existing intelligent auxiliary diagnosis methods of PFPS mainly focused on the biosignal of individuals but neglected the common biometrics of patients. In this paper, we propose a PFPS classification method based on the fused biometrics information Graph Convolution Neural Networks (FBI-GCN) which focuses on both the biosignal information of individuals and the common characteristics of patients. The method first constructs a graph which uses each subject as a node and fuses the biometrics information (demographics and gait biosignal) of different subjects as edges. Then, the graph and node information [biosignal information, including the joint kinematics and surface electromyography (sEMG)] are used as the inputs to the GCN for diagnosis and classification of PFPS. The method is tested on a public dataset which contain walking and running data from 26 PFPS patients and 15 pain-free controls. The results suggest that our method can classify PFPS and pain-free with higher accuracy (mean accuracy = 0.8531 ± 0.047) than other methods with the biosignal information of individuals as input (mean accuracy = 0.813 ± 0.048). After optimal selection of input variables, the highest classification accuracy (mean accuracy = 0.9245 ± 0.034) can be obtained, and a high accuracy can still be obtained with a 40% reduction in test variables (mean accuracy = 0.8802 ± 0.035). Accordingly, the method effectively reflects the association between subjects, provides a simple and effective aid for physicians to diagnose PFPS, and gives new ideas for studying and validating risk factors related to PFPS.

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