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1.
Nat Prod Res ; : 1-8, 2023 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-37812182

RESUMO

A preliminary screening test was performed to discover new antihyperlipidaemic active compounds from the leguminous plant Derris eriocarpa How. A new compound, derris-isoflavone F (1), and derrubone dimethyl ether (6), a known synthetic compound of natural origin, were isolated from the stems of D. eriocarpa alongside eight recognised compounds. To our knowledge, this is the first instance of documenting the identification of compounds 1-10 from this plant. The new compound were evaluated for their antihyperlipidemic and antiproliferative properties. Compound 1 evidently reduced the triglyceride (TG) content in oleic acid-treated HepG2 cells, which validated its efficacy as a potential TG-lowering agent.

2.
Spectrochim Acta A Mol Biomol Spectrosc ; 288: 122191, 2023 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-36463623

RESUMO

In this work, a novel triphenylamine-benzofuran derived fluorescent probe, TBF-SS, was developed for detecting hydrogen polysulfide in tea samples and intracellular imaging. TBF-SS showed the practical advantages including high sensitivity (LOD = 0.01 µM), high selectivity, rapid response (within 15 min), and steadiness in various environmental conditions. The detecting system was steady within pH range of 6.0-11.0 and temperature range of 20-55 °C. The probe TBF-SS could guarantee the stable detection of H2Sn for 7 d in storage of either solid or solution. In particular, in the application of various tea samples with different brewing times and testing temperatures, the recovery percentages varied in the range of 95.22 % to 105.0 %. Therefore accurate monitoring of H2Sn could be achieved by using the probe TBF-SS. In addition, TBF-SS could monitor the exogenous level, the ß-lapachone-induced generation and the tea-sample-treated introduction of H2Sn in living MCF-7 cells. This work might inspire the improvement of the serviceability of fluorescent implements.


Assuntos
Benzofuranos , Corantes Fluorescentes , Hidrogênio/análise , Chá
3.
J Asian Nat Prod Res ; 17(10): 1002-9, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26275038

RESUMO

Derris eriocarpa How is an important medicinal plant, which is used as Zhuang ethnomedicine and Dai ethnomedicine to treat various diseases. One new compound, 3',4'-di-O-methylene-5-hydroxy-7-methoxy-6-isopentenyl isoflavone (1) and a known synthetic but new naturally occurring compound trans-3,4,5-trimethoxy-4'-isopentenyloxyl-stilbene (2), together with five known compounds, 5,7-dimethoxy-6-(3-methyl-2-butenyl)-4'-hydroxyl isoflavones (3), robustone (4), trans-3,4,5,4'-tetramethoxy-stilbene (5), robustic acid (6), and robustin (7) were isolated from the stem of D. eriocarpa. Spectroscopic analysis revealed the chemical structures of compounds 1-7.. Compounds 1 and 3 exhibited significant scavenging activities against 1,1-diphenyl-2-picrylhydrazyl radical and superoxide anions. Compounds 1-3 exhibited potent antiproliferative activity on Hela cells.


Assuntos
Antineoplásicos/isolamento & purificação , Antineoplásicos/farmacologia , Derris/química , Sequestradores de Radicais Livres/isolamento & purificação , Sequestradores de Radicais Livres/farmacologia , Isoflavonas/isolamento & purificação , Isoflavonas/farmacologia , Antineoplásicos/química , Compostos de Bifenilo/química , Compostos de Bifenilo/farmacologia , Sequestradores de Radicais Livres/química , Células HeLa , Humanos , Isoflavonas/química , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Picratos/química , Picratos/farmacologia , Caules de Planta/química , Plantas Medicinais/química , Estilbenos/química
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