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Int J Nanomedicine ; 19: 4321-4337, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38770103

RESUMO

Purpose: Cannabidiol (CBD) is a promising therapeutic drug with low addictive potential and a favorable safety profile. However, CBD did face certain challenges, including poor solubility in water and low oral bioavailability. To harness the potential of CBD by combining it with a transdermal drug delivery system (TDDS). This innovative approach sought to develop a transdermal patch dosage form with micellar vesicular nanocarriers to enhance the bioavailability of CBD, leading to improved therapeutic outcomes. Methods: A skin-penetrating micellar vesicular nanocarriers, prepared using nano emulsion method, cannabidiol loaded transdermal nanocarriers-12 (CTD-12) was presented with a small particle size, high encapsulation efficiency, and a drug-loaded ratio for CBD. The skin permeation ability used Strat-M™ membrane with a transdermal diffusion system to evaluate the CTD and patch of CTD-12 (PCTD-12) within 24 hrs. PCTD-12 was used in a preliminary pharmacokinetic study in rats to demonstrate the potential of the developed transdermal nanocarrier drug patch for future applications. Results: In the transdermal application of CTD-12, the relative bioavailability of the formulation was 3.68 ± 0.17-fold greater than in the free CBD application. Moreover, PCTD-12 indicated 2.46 ± 0.18-fold higher relative bioavailability comparing with free CBD patch in the ex vivo evaluation. Most importantly, in the pharmacokinetics of PCTD-12, the relative bioavailability of PCTD-12 was 9.47 ± 0.88-fold higher than in the oral application. Conclusion: CTD-12, a transdermal nanocarrier, represents a promising approach for CBD delivery, suggesting its potential as an effective transdermal dosage form.


Assuntos
Administração Cutânea , Disponibilidade Biológica , Canabidiol , Portadores de Fármacos , Nanopartículas , Absorção Cutânea , Adesivo Transdérmico , Canabidiol/farmacocinética , Canabidiol/química , Canabidiol/administração & dosagem , Animais , Absorção Cutânea/efeitos dos fármacos , Portadores de Fármacos/química , Portadores de Fármacos/farmacocinética , Masculino , Nanopartículas/química , Ratos , Ratos Sprague-Dawley , Tamanho da Partícula , Pele/metabolismo , Pele/efeitos dos fármacos , Micelas
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