[Spatiotemporal Interaction Characteristics and Transition Mechanism of Carbon Intensity in China's Transportation Industry].

This research was conducted using many spatial analysis approaches to dissect the spatiotemporal interactive characteristics of carbon emission intensity within the transportation sector from 2002 to 2020. An in-depth exploration of their transition mechanisms was conducted by nesting the obtained timewarp types with the panel quantile model. Finally, the geodetector model aligned with different transition mechanisms was employed to investigate and analyze the interaction effects among various factors influencing carbon intensity in the transportation sector. The results indicated that:① The carbon emission intensity of the transportation sector in 30 provinces and regions of China showed an overall downward trend with fluctuations, and the spatial clustering level was relatively stable. ② The spatiotemporal interactive features of ESTDA revealed that the relationship between the northwest region and its adjacent spatial units was unstable, with significant variations and fluctuations. In contrast, economically developed areas such as coastal cities in the eastern part had established mature transportation networks, resulting in a relatively stable local spatial pattern, though a few areas still exhibited spatiotemporal competitiveness. ③ The spatiotemporal transition of carbon intensity in the transportation sector could be categorized into four driving or constraining modes(the population economy urbanization constraint model, population economy urbanization facility constraint model, technology consumption industry-driven model, and technology industry regulation-driven model). Most provinces were influenced by the low quantile constraint and high quantile drive modes, with only a few affected by the high quantile constraint and low quantile drive modes, the majority of which were located in the northwest or southwest regions. ④ Further, we introduced the geographical detector model based on the identified mechanism of carbon emission intensity transition in the transportation sector, emphasizing the coordinated development of multiple factors and strengthening inter-regional collaborative governance.

Role of FSCN1 in the tumor microenvironment of lung squamous cell carcinoma.

Tumor microenvironment (TME) regulated the development of the Lung squamous cell carcinoma (LUSC). To know more about the LUSC, this study tried to figure the role of fscin actin-bundling protein 1 (FSCN1) in the TME. We identified the FSCN1 as the hub immune gene in LUSC, with the use of weighted gene co-expression network analysis (WGCNA) and the Human Protein Atlas. Furthermore, we verified the higher expression of FSCN1 in LUSC compared with the normal tissues by quantitative reverse transcription PCR (qRT-PCR) and immunohistochemistry. We then explored the associations among FSCN1, immune infiltrations, and inflammatory factors with the use of Gene Expression Profiling Interactive Analysis (GEPIA) and Tumor IMmune Estimation Resource (TIMER). As a result, the expressions of FSCN1 was negatively related to the immune infiltrations, and positively related to the expressions of IL1A, IL1B, TGFB1 and TGFA. Moreover, we used the single-cell RNA-sequencing (scRNA-seq) data of LUSC to figure out the expressions level of FSCN1, IL1A, IL1B, TGFB1 and TGFA in the different cell type's of the TME. Finally, through the cytological experiments, we found that FSCN1 affected by TGFB1 contributes to the proliferation, anti-apoptotic effect, migration and invasion of the LUSC cells. In summary, this study Identified FSCN1 as the potential therapeutic target of LUSC, and reveals a complicated immune and inflammatory net in the TME.

Channel Crack-Designed Gold@PU Sponge for Highly Elastic Piezoresistive Sensor with Excellent Detectability.

It is a great challenge to fabricate piezoresistive sensors that possess high elasticity, large-area compliance, and excellent detectability to satisfy both extremely tiny and large human activity monitoring. Herein, a novel and facile strategy is reported to manufacture highly elastic channel crack-based gold@PU sponge piezoresistive material. The elastic 3D conductive network is successfully prepared by gold ion sputtering, and channel cracks are skillfully designed on the 3D sponge skeletons. Such novel structure makes these fabricated sensors are capable of monitoring both tiny and large human motions, which originate from the nanocrack joint sensing mechanism and physical contact of conductive interconnected network. Meanwhile, our sensors possess excellent elasticity, fast response time (9 ms), and ultralow detection limit (0.568 Pa), as well as good reproducibility over 1000 cycles. The desirable elasticity of channel crack-based gold@PU sensor is comparable to recently reported pressure sensors, together with advantages of reliable fabrication and large-area compliance, makes them attractive in various electronic devices, for example, biological health monitoring, sport performance monitoring, and man-machine interfaces.

Structural features of a pectic polysaccharide from mulberry leaves.

A pectic polysaccharide SDA was obtained from the boiling water extract of mulberry leaves. It consisted of rhamnose, arabinose, xylose, glucose, galactose, and galacturonic acid units in the molar ratio of 5:4:1:2:6:38. Its molecular weight was determined to be 1.5 x 10(4) by high-performance gel filtration chromatography. A combination of linkage analysis, partial acid hydrolysis, ESIMS, (1)H-NMR, and (13)C-NMR spectral analyses revealed its structural features. It was found that SDA possessed an alpha-(1 --> 4)-galacturonan backbone with some insertions of (1 --> 2) Rha residues, with the side chains attached to the O-3 or O-2 position of GalA residues, or the O-4 position of 1,2-linked Rha residues. The side chains contained branched (1 --> 5) linked arabinan, branched (1 --> 3) linked rhamman, linear (1 --> 4) linked xylan, linear (1 --> 4) linked glucan, and linear (1 --> 2) linked galactan. SDA was a new acidic polysaccharide isolated from mulberry leaves for the first time.