The non-linear associations of serum follicle-stimulating hormone levels with bone mineral density and the risk of osteoporosis during menopausal transition: an analysis of National Health and Nutrition Examination Survey data.

PURPOSE: To explore the non-linear associations of serum FSH levels with BMD and the risk of osteoporosis in pre- and postmenopausal women. METHODS: Data analyzed in this study were derived from the National Health and Nutrition Examination Survey (NHANES) III and the NHANES from 1999 to 2002. Women aged from 35 to 60 years with complete data of serum FSH levels and BMD were eligible. Serum FSH levels were assayed using the Microparticle Enzyme Immunoassay technology. Lumbar spine and femur neck BMD were measured using a dual energy X-ray absorptiometry. Osteoporosis was assessed according to BMD of lumbar spine, total femur, and femur neck. RESULTS: This study included 3743 women. A significant non-linear association of serum FSH levels with lumbar spine BMD was observed only in postmenopausal women (P for non-linear association = 0.013) but not in premenopausal women (P for non-linear association = 0.092). The results of femur neck BMD were comparable with those of lumbar spine BMD. Meanwhile, there was significant non-linear association of serum FSH levels with the risk of osteoporosis only in postmenopausal women (P for non-linear association = 0.050). CONCLUSION: Non-linear associations of serum FSH levels with BMD at lumbar spine and femur neck were observed only in postmenopausal women. Meanwhile, serum FSH levels were non-linearly associated with the risk of osteoporosis in postmenopausal women.

Baduanjin exercise in the treatment of hypertension: A systematic review and meta-analysis.

Background: As a therapy to prevent and treat hypertension, exercise is widely used in clinical practice. But due to the lack of documentary evidence, Baduanjin as a relaxed and convenient mode of exercise is not currently recommended by professional health organizations to treat hypertension. The purpose of this article is to examine the efficacy of Baduanjin as an antihypertensive exercise therapy. Methods: Our systematic retrieved of the entire relevant literatures in 12 databases. Finally, 28 eligible trials involving Baduanjin intervention in hypertension were included. After the quality assessment and bias risk assessment of the included trials, we analyzed the blood pressure values before and after the intervention, and performed meta-analysis on the random effect results. In order to explore the factors influencing the decrease of blood pressure, we also performed a subgroup analysis of the results. Results: Participants (n = 2121) were adults (61.74 ± 5.85years of age, mean ± SD), with baseline blood pressure (systolic blood pressure (SBP) = 150.7 ± 9.2 mmHg, diastolic blood pressure (DBP) = 93.2 ± 8.8 mmHg). Baduanjin was practiced 7.5 ± 3.8 sessions / week for 28.2 ± 12.8 min /session for 16.7 ± 9.2 weeks. Overall, Baduanjin resulted in SBP (-9.3 mmHg, d = -1.49, 95%CI: -1.73 to -1.13) and DBP (-6.3 mmHg, d = -1.20, 95%CI: -1.51 to -0.88) vs. the control group (p < 0.001). After a subgroup analysis of age, we found that SBP heterogeneity was significantly reduced in the elderly group. Conclusion: Our results indicate that Baduanjin can effectively reduce blood pressure (i.e., 9.3 mmHg and 6.3 mmHg of SBP and DBP reductions, respectively), and reduce the incidence rate of cardiovascular disease in hypertensive patients. In addition, we will be more likely to recommend that the elderly exercise Baduanjin.

Follicle-stimulating hormone and blood lead levels with bone mineral density and the risk of fractures in pre- and postmenopausal women.

Background: The conclusions on the associations of serum follicle-stimulating hormone (FSH) and blood lead levels with bone mineral density (BMD) were controversial. Furthermore, little was known on the impacts of co-existence of serum FSH and blood lead levels on BMD and the risk of fractures in premenopausal and postmenopausal women. Therefore, the present study aimed to examine the associations of serum FSH and blood lead levels with BMD and the risk of fractures in premenopausal and postmenopausal women. Methods: Data were derived from the National Health and Nutrition Examination Survey. FSH is assayed using the Microparticle Enzyme Immunoassay technology. Blood lead levels were measured using atomic absorption spectrometry. BMD was measured using dual energy X-ray absorptiometry. Fractures were defined as subjects with fractures in any site of hip, wrist, and spine. Results: This study included 3798 participants. Elevated blood lead levels were associated with increased serum FSH levels (ß= 48.22, 95% CI: 40.21~ 56.22). Serum FSH levels were negatively associated with total femur BMD in pre- and postmenopausal women. However, elevated serum FSH levels were associated with a lower lumbar spine BMD and a higher risk of fractures only in postmenopausal women (ß= -0.0010, 95% CI: -0.0015~ -0.0006; OR: 1.007, 95% CI: 1.000~1.014, respectively). Conclusions: Serum lead levels were associated with serum FSH levels. Serum FSH levels were associated with a lower BMD and a higher risk of fractures.

Prognosis Comparisons of Laparoscopy versus Open Surgery for Rectal Cancer Patients after Preoperative Chemoradiotherapy: A Meta-Analysis.

AIM: We aimed to compare the oncological outcomes of laparoscopy and open resection for patients with rectal cancer following neoadjuvant chemoradiotherapy (NCRT). METHODS: We searched the publications that compared the efficacy of laparoscopic surgery and open thoracotomy in treatment outcomes of rectal cancer after NCRT. All trials analyzed the summary hazard ratios of the endpoints of interest, including survival and individual postoperative complications. RESULTS: Totally, 10 trials met our inclusion criteria. The pooled analysis of 3-year disease-free survival (OR 1.39, 95% CI 0.93-2.06; p = 0.11) and 3-year overall survival (OR 1.01, 95% CI 0.70-1.45; p = 0.97) showed that laparoscopic surgery did not achieve beneficial effects compared with open thoracotomy. The pooled result of duration of surgery indicated that laparoscopic surgery was associated with a trend for longer surgery time (SMD 27.53, 95% CI 1.34-53.72; p = 0.04), shorter hospital stay (SMD -1.64, 95% CI -2.70 to -0.58; p = 0.002), more postoperative complications (OR 0.77, 95% CI 0.60-0.99; p = 0.04), and decreased blood loss (SMD -49.87, 95% CI -80.61 to -19.14; p = 0.001). However, the number of removed lymph nodes, positive circumferential resection margin, as well as complications after surgery showed significant differences between the 2 groups. CONCLUSIONS: We focused on current evidence and reviewed the studies indicating that similar oncological outcomes were associated with laparoscopic surgery following NCRT for patients with locally advanced lower rectal cancer in comparison with open surgery.

A Systematic Review and Meta-Analysis of the Effects of Perioperative Immunonutrition in Gastrointestinal Cancer Patients.

In this systematic review and meta-analysis, 25 clinical trials were systematically reviewed, and meta-analysis was performed with the results of 16 trials. It was found that the risk of surgical site infection was significantly lower in patients who received perioperative immunonutrition than those given standard nutrition. Furthermore, hospital stay was significantly shorter in patients receiving immunonutrition or early enteral nutrition after surgical resection of gastric cancer. Perioperative immunonutrition also significantly reduced white blood cell counts and the level of C-reactive protein in the patients. However, neither CD4+ T cells nor inflammatory cytokines were significantly affected even though immunonutrition was in favor. These findings suggested that patients with gastrointestinal cancer may benefit from perioperative immunonutrition support by reducing surgery-associated complications and shortening hospital stay. The effects and the underlying mechanism of immunonutrition on immunological modulation and inflammatory regulation, however, remain to be further defined.