[The effect of lithium oxybutyrate on the development of the fetus and progeny in alcoholic intoxication of male rats]. / Vliianie litiia oksibutirata na razvitie ploda i potomstva v usloviiakh alkogol'noi intoksikatsii samtsov krys.

The effect of lithium hydroxybutyrate on the development of the fetus and offsprings was studied on a model of alcohol intoxication of male rats. Under such conditions lithium hydroxybutyrate relieved completely the negative action of alcohol on the reproductive function, according to all parameters. The learning ability of the offsprings and their behavioral disorders in a stress situation caused by alcohol were normalized. Two-week administration of 100 mg/kg lithium hydroxybutyrate had no negative effect on the embryonal and postnatal development of the offsprings.

[The effect of fenazepam and phenobarbital administered prenatally and in the early postnatal period on the behavioral reactions of rat progeny]. / Vliianie fenazepama i fenobarbitala, vvodimykh v prenatal'nom i rannem postnatal'nom periodakh, na povedencheskie reaktsii potomstva krys.

Phenazepam, 10 mg/kg/day, or phenobarbital, 30 mg/kg/day, administered to female rats during the entire pregnancy and 5 days after delivery during lactation induced behavioral changes in their offsprings at early (1.5-2 months) and later (4 months) ages. Phenobarbital produced a more marked effect on the central nervous system than phenazepam by causing impairments of extrapolatory reflexes and behavioral stereotype in a conflict situation or open field.

[The effect of fenazepam and phenobarbital on the course of pregnancy in rats and on the early postnatal development of their progeny]. / Vliianie fenazepama i fenobarbitala na techenie beremennosti krys i rannee postnatal'noe razvitie ikh potomstva.

Examining the effects of phenazepam and phenobarbital on the course of pregnancy and the development of offsprings has revealed that phenobarbital that has an embryotoxic effect reduced the number of rat offsprings and diminished their weight, but failed to affect the behavioral responses of newborn rats. On the contrary, phenazepam had no embryotoxic effect, but on entering the newborn rats' organism with milk it inhibited some behavioral reactions in the early postnatal period.

[The influence of modulators of enzyme activity on the pharmacological effect of thiopental sodium and ketamine and on the pharmacokinetics of thiopental sodium]. / Vliianie moduliatorov aktivnosti fermentov na farmakologicheskii éffekt tiopentala-natriia i ketamina i farmakokinetiku tiopentala-natriia.

The rat experiments studied the impact of inductors and inhibitors of enzymatic activity of xenobiotic metabolism on the pharmacological activity of sodium thiopental and ketamine and on the pharmacokinetics of sodium thiopental. Cocarboxylase, cobalt chloride and cimetidine enhanced the pharmacological action of sodium thiopental, but failed to exert any action on the effect of ketamine. The preparations of vitamin K, particularly vikasol and menadione sodium bisulfite, and phenobarbital attenuated the effects of these anesthetics, but tocopherol unchanged it. Phenobarbital and vikasol accelerated blood elimination of sodium thiopental, whereas cimetidine and cocarboxylase slowed down this process.

[The prolonged use of calcium antagonists in myocardial infarct in rats: their effect on hemodynamics and the contractile function and morphology of the heart muscle]. / Dlitel'noe primenenie antagonistov kal'tsiia pri infarkte miokarda u krys: vliianie na gemodinamiku, sokratitel'nuiu funktsiiu i morfologiiu serdechnoi myshtsy.

Experiments on rats with myocardial infarction induced by occlusion of the left coronary artery were made to explore the influence of calcium antagonists injected intraperitoneally for a long time (daily, for 21 days) on hemodynamics, contractile function and morphology of the heart muscle. It has been shown that verapamil (0.5 mg/kg), diltiazem (2 mg/kg) and nimodipine (20 micrograms/kg) do not exert under those conditions any noticeable effect on pump and contractile heart functions. Administration of verapamil in a doze of 2 mg/kg enhanced heart failure. The drugs under study normalized the response of contractile heart function to volumetric load, which is related to a considerable measure to the acceleration of reparative processes in the myocardium.

[The nooglutil correction of functional disorders of the central nervous system caused by prenatal alcoholization in rats]. / Korrektsiia noogliutilom narushenii funktsii tsentral'noi nervnoi sistemy, vyzvannykh prenatal'noi alkogolizatsiei u krys.

Administration of ethanol (5 g/kg/day, per os) to the pregnant rats evoked delayed impairments of the learning and memory in the offspring. Prenatal alcoholization of the animals attenuated the habituation of the exploration behavior in open field, impaired acquisition and retention of active avoidance in a shuttle box, increased slow activity of the EEG spectrum power, disturbed the function of the serotoninergic system in the brain cortex and of the dopaminergic system in the hippocamp. The new nootropic drug nooglutyl (N-5/hydroxynicotinoyl/-L-glutamic acid) administered in a dose of 25 mg/kg/day from the 8th to the 20th day of life prevented the above-mentioned delayed disturbances of higher integrative functions and biochemical processes in rat brain.

[The effect of ziksorin on the development of experimental food anaphylaxis in guinea pigs]. / Vliianie ziksorina na razvitie éksperimental'noi pishchevoi anafilaksii u morskikh svinok.

A study was made of the effect of zixorin, an inductor of liver cytochrome P-450, on the intensity of the immediate type allergic reaction--active food anaphylaxis in response to ovalbumin in guinea-pigs. Intraperitoneal injection of zixorin in a dose of 50 mg/kh for 3 days before administration of the antigen resolution dose was found to lower 2,3-fold the level of lethal outcomes due to the anaphylactic shock. It is suggested that zixorin may be used in multimodality treatment of food allergy.

[The lithium oxybutyrate correction of disorders in higher nervous activity in the progeny of alcoholized male rats]. / Korrektsiia litiia oksibutiratom narushenii vysshei nervnoi deiatel'nosti potomstva alkogolizirovannykh krys-samtsov.

In experiments on rats it was shown that alcohol administered intragastrically in a dose of 8 g/kg for 4 weeks produced long-term disturbances of CNS function in the offspring similar to those observed under clinical conditions. Early postnatal administration of lithium oxybutyrate (from the 8th through the 14th day of life) was found to prevent the development of the disturbances.

[An experimental study of the safety of the preparation bonnecor in trials on dogs]. / Eksperimental'noe izuchenie bezopasnosti preparata bonnekora v oytakh na sobakakh.

The preclinical study of safety of an antiarrhythmic drug bonnecor (GS-015) was carried out in the experiments on dogs. Administration of the drug in a dose of 5 mg/kg was found to exert no significant effect on functions of the vital organs. The dosage of 15 mg/kg can produce in dogs changes of the hematological and biochemical parameters and cause functional disorders of the cardiac muscle and death of the animals. The data obtained indicate that in dogs the drug possesses a little therapeutic range.

[A preclinical study on the safety of a new antialcoholic drug inmecarb]. / Doklinicheskoe issledovanie bezopasnosti novogo protivoalkogol'nogo preparata inmekarba.

A preclinical study on safety of a new antialcoholic drug inmecarb was carried out on three species of experimental animals (rats, guinea pigs, dogs) receiving the drug at different doses including a subtoxic one (1/5 of LD50) for 6 months. The authors concluded that on the basis of a relatively low toxicity and the absence of specific toxicity and long-term side effects the drug may be recommended for clinical use as an antialcoholic agent.

[Effect of teturam on the development of the offspring of alcoholized animals]. / Vliianie teturama na razvitie potomstva alkogolizirovannykh zhivotnykh.

During experiments on rats it was found that in alcoholized animals teturam on the whole did not potentiate and in some cases even attenuated the toxic effect of alcohol on the offspring development. The data confirm the idea about necessity of studying toxicity of drugs under the conditions corresponding to their clinical use.

[Toxicological characteristics of teturam in an alcoholic intoxication model in rats]. / Toksikologicheskaia kharakteristika teturama na modeli alkogol'noi intoksikatsii u krys.

Study of toxicological characteristic of teturam (200 mg/kg, administered into the stomach through a tube daily for 2 weeks) on the model of alcoholic intoxication in rats (ethanol, 8 g/kg, administered into the stomach through a tube daily for 1 month) confirmed the literature data on the drug's ability to enhance or maintain ethanol-induced pathological changes in the blood and internal organs.

[Experimental verification of the use of lithium oxybutyrate for the drug prevention of alcoholism relapses]. / Eksperimental'noe obosnovanie primeneniia litiia oksibutirata dlia farmakoprofilaktiki retsidivov alkogolizma.

It was found that lithium oxybutyrate suppresses voluntary consumption of 5% ethanol solution in rats with preliminarily formed alcohol motivation, slows down the formation of alcohol addiction under conditions of forced consumption of 5% ethanol solution and exerts a positive effect on general state of the animals subjected to a long-term action of ethanol by improving the conditioned reflex activity of the central nervous system and stimulating defensive-adaptational mechanisms of the organism.

[Effect of lithium oxybutyrate on the viability of preserved donor kidney]. / Vliianie litiia oksibutirata na zhiznesposobnost' konservirovannoi donorskoi pochki.

The experiments on 10 dogs showed that replacement of sodium oxybutyrate for lithium oxybutyrate in the solution for preservation increases the period of preserving the structural and functional integrity of the donor kidney, contributes to its survival and delays the development of the transplant rejection.

[Electrophysiological and morphological analysis of the cardiotoxic action of ethanol in rats]. / Elektrofiziologicheskii i morfologicheskii analiz kardiotoksicheskogo deistviia étanola u krys.

The experiments on male rats showed that oral ethanol administered in a dose of 8 g/kg (2/3 of LD50) daily for a month produces toxic heart damage whose electrophysiological and morphological characteristics are similar to clinico-anatomical manifestations of human alcohol myocardiodystrophy. It was concluded that the model may be used for the search of new pharmacological agents for the treatment and prevention of alcohol myocardiodystrophy.

[Method for the quantitative evaluation of the effect of drugs and other factors on the viability of an ischemic skin flap]. / Sposob kolichestvennoi otsenki vliianiia lekarstvennykh sredstv i drugikh faktorov na zhiznesposobnost' ishemizirovannogo kozhnogo loskuta.

The use of a skin graft from the leg or back of mice or rats (10 X 20 mm) or rats (12 X 52 mm) with its further packing results in the 50 +/- 10% ruin of the distal part. The effect of different factors on necrosis change in size is quantitatively evaluated.

[Effect of drugs on the viability of a pedicled skin flap in mice]. / Vliianie lekarstvennykh sredstv na vyzhivaemost' kozhnogo loskuta na nozhke u myshei.

In experiments on random-bred white male mice it was shown that medicinal agents, applied for various purposes in dermatoplasty operations, exert different influence on the size of necrosis of a skin flap on a feeding pedicle.