1.
Dokl Akad Nauk SSSR
; 318(2): 459-66, 1991.
Artigo
em Russo
| MEDLINE
| ID: mdl-1893839
Assuntos
Inibidores da Colinesterase/farmacologia , Compostos Organofosforados/farmacologia , Acetilcolinesterase/sangue , Animais , Butirilcolinesterase/sangue , Inibidores da Colinesterase/farmacocinética , Relação Dose-Resposta a Droga , Interações Medicamentosas , Cavalos , Humanos , Técnicas In Vitro , Matemática , Compostos Organofosforados/farmacocinética , Fosforilação , Fatores de Tempo
2.
Vopr Med Khim
; 31(3): 99-103, 1985.
Artigo
em Russo
| MEDLINE
| ID: mdl-3861024
RESUMO
Effect of inactive precursor of alpha-thrombin--prethrombin (Pre-I) and prostaglandin (PGE2) on aggregation of washed rat platelets induced by alpha-thrombin was studied. Pre-I inhibited dose-dependently the alpha-thrombin-induced platelet aggregation. K1 values for Pre-I of high and low affinity binding sites were equal to 0.9.10(-8) M and 0.56.10(-6) M, respectively. PGE2 inhibited the alpha-thrombin-induced aggregation after simultaneous addition and within 5 and 15 min of incubation with PGE2. Preincubation of platelets with alpha-thrombin within 15 min prevented the PGE2-induced aggregation but preincubation of platelets with Pre-I within 15 min did not influence the platelet aggregation, induced by PGE2.