RESUMO
Overall 30 patients with multiple myeloma (MM) were examined for immunological and rheological parameters. MM was shown to be marked by imbalance of immunobiological reactivity, with the greatest changes being seen in the B cell immunity system. MM is also characterized by marked rheological shifts related to the immunological alterations and underlying the hyperviscosity syndrome and heart failure. Administration of polychemotherapy resulted in a decrease of the count of B lymphocytes, circulating immune complexes; a tendency toward normalization of the rheological blood properties was observed. Introduction of plasmapheresis into the treatment program of the patients noticeably raised the treatment efficacy.
Assuntos
Viscosidade Sanguínea , Mieloma Múltiplo/imunologia , Adulto , Idoso , Antineoplásicos/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Viscosidade Sanguínea/efeitos dos fármacos , Doença Crônica , Ciclofosfamida/administração & dosagem , Daunorrubicina/administração & dosagem , Feminino , Insuficiência Cardíaca/etiologia , Humanos , Imunidade Celular/efeitos dos fármacos , Imunidade Celular/imunologia , Falência Renal Crônica/etiologia , Masculino , Melfalan/administração & dosagem , Pessoa de Meia-Idade , Mieloma Múltiplo/sangue , Mieloma Múltiplo/complicações , Mieloma Múltiplo/tratamento farmacológico , Compostos de Mostarda Nitrogenada/administração & dosagem , Prednisolona/administração & dosagem , Vincristina/administração & dosagemRESUMO
In patients with purulent peritonitis, the severe immunodepression and suppression of proliferative activity of stem elements of hemopoietic tissue stroma were revealed. The effectiveness of the use as an immunomodulator of the preparation "Antilympholin" which has the marked immunostimulating properties is shown.