1.
Bioorg Med Chem Lett
; 5(1): 83-88, 1995 Jan 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30294073
RESUMO
Cyclic sulfone-3-carboxamides are effective P2-1igands for HIV-1 protease inhibitors. Incorporation of 3S-tetrahydro-2H-thiopyrancarboxamide-l, l-dioxide in the hydroxyethylamine series resulted in inhibitor 14 (IC50=9 nM, CIC95=200 nM) with improved potency compared to its corresponding urethane derivative 18 (IC50=2.0 µM).