Systematic population-wide ecological analysis of regional variability in disease prevalence.

The prevalence of diseases often varies substantially from region to region. Besides basic demographic properties, the factors that drive the variability of each prevalence are to a large extent unknown. Here we show how regional prevalence variations in 115 different diseases relate to demographic, socio-economic, environmental factors and migratory background, as well as access to different types of health services such as primary, specialized and hospital healthcare. We have collected regional data for these risk factors at different levels of resolution; from large regions of care (Versorgungsregion) down to a 250 by 250 m square grid. Using multivariate regression analysis, we quantify the explanatory power of each independent variable in relation to the regional variation of the disease prevalence. We find that for certain diseases, such as acute heart conditions, diseases of the inner ear, mental and behavioral disorders due to substance abuse, up to 80% of the variance can be explained with these risk factors. For other diagnostic blocks, such as blood related diseases, injuries and poisoning however, the explanatory power is close to zero. We find that the time needed to travel from the inhabited center to the relevant hospital ward often contributes significantly to the disease risk, in particular for diabetes mellitus. Our results show that variations in disease burden across different regions can for many diseases be related to variations in demographic and socio-economic factors. Furthermore, our results highlight the relative importance of access to health care facilities in the treatment of chronic diseases like diabetes.

Exploitation and exploration in text evolution. Quantifying planning and translation flows during writing.

Writing is a complex process at the center of much of modern human activity. Despite appearing to be a linear process, writing conceals many highly non-linear processes. Previous research has focused on three phases of writing: planning, translation and transcription, and revision. While research has shown these are non-linear, they are often treated linearly when measured. Here, we introduce measures to detect and quantify subcycles of planning (exploration) and translation (exploitation) during the writing process. We apply these to a novel dataset that recorded the creation of a text in all its phases, from early attempts to the finishing touches on a final version. This dataset comes from a series of writing workshops in which, through innovative versioning software, we were able to record all the steps in the construction of a text. 61 junior researchers in science wrote a scientific essay intended for a general readership. We recorded each essay as a writing cloud, defined as a complex topological structure capturing the history of the essay itself. Through this unique dataset of writing clouds, we expose a representation of the writing process that quantifies its complexity and the writer's efforts throughout the draft and through time. Interestingly, this representation highlights the phases of "translation flow", where authors improve existing ideas, and exploration, where creative deviations appear as the writer returns to the planning phase. These turning points between translation and exploration become rarer as the writing process progresses and the author approaches the final version. Our results and the new measures introduced have the potential to foster the discussion about the non-linear nature of writing and support the development of tools that can lead to more creative and impactful writing processes.

Color associations in abstract semantic domains.

The embodied cognition paradigm has stimulated ongoing debate about whether sensory data - including color - contributes to the semantic structure of abstract concepts. Recent uses of linguistic data in the study of embodied cognition have been focused on textual corpora, which largely precludes the direct analysis of sensory information. Here, we develop an automated approach to multimodal content analysis that detects associations between words based on the color distributions of their Google Image search results. Crucially, we measure color using a transformation of colorspace that closely resembles human color perception. We find that words in the abstract domains of academic disciplines, emotions, and music genres, cluster in a statistically significant fashion according to their color distributions. Furthermore, we use the lexical ontology WordNet and crowdsourced human judgments to show that this clustering reflects non-arbitrary semantic structure, consistent with metaphor-based accounts of embodied cognition. In particular, we find that images corresponding to more abstract words exhibit higher variability in colorspace, and semantically similar words have more similar color distributions. Strikingly, we show that color associations often reflect shared affective dimensions between abstract domains, thus revealing patterns of aesthetic coherence in everyday language. We argue that these findings provide a novel way to synthesize metaphor-based and affect-based accounts of embodied semantics.

Quantification of the resilience of primary care networks by stress testing the health care system.

There are practically no quantitative tools for understanding how much stress a health care system can absorb before it loses its ability to provide care. We propose to measure the resilience of health care systems with respect to changes in the density of primary care providers. We develop a computational model on a 1-to-1 scale for a countrywide primary care sector based on patient-sharing networks. Nodes represent all primary care providers in a country; links indicate patient flows between them. The removal of providers could cause a cascade of patient displacements, as patients have to find alternative providers. The model is calibrated with nationwide data from Austria that includes almost all primary care contacts over 2 y. We assign 2 properties to every provider: the "CareRank" measures the average number of displacements caused by a provider's removal (systemic risk) as well as the fraction of patients a provider can absorb when others default (systemic benefit). Below a critical number of providers, large-scale cascades of patient displacements occur, and no more providers can be found in a given region. We quantify regional resilience as the maximum fraction of providers that can be removed before cascading events prevent coverage for all patients within a district. We find considerable regional heterogeneity in the critical transition point from resilient to nonresilient behavior. We demonstrate that health care resilience cannot be quantified by physician density alone but must take into account how networked systems respond and restructure in response to shocks. The approach can identify systemically relevant providers.