RESUMO
The effects of naloxone infusion on plasma prolactin (PRL) levels and on the PRL response to mechanical breast emptying were investigated in a group of puerperal women, Five, 10, and 20 mg naloxone administered to women on days 2 to 3 of the puerperium produced no significant change in serum PRL. The same dose of naloxone had no significant effect on serum PRL response to mechanical breast stimulation in puerperal women. The results suggest that endogenous opioid peptides are not major modulators of PRL secretion in the puerperium.
Assuntos
Lactação , Naloxona/administração & dosagem , Período Pós-Parto , Prolactina/metabolismo , Adulto , Feminino , Humanos , Infusões Parenterais , Métodos , GravidezRESUMO
The effects of a 5 day course of Piribedil, a dopaminergic agonist, on prolactin release evoked by mechanical breast emptying in puerperal women, was investigated. A daily dose of 75 mg. caused a significant decrease in the prolactin response to mechanical breast stimulation. Piribedil also proved clinically useful in inhibiting lactation. The role of dopaminergic mechanisms in the regulation of prolactin release induced by mechanical breast emptying are discussed.
Assuntos
Lactação/efeitos dos fármacos , Piperazinas/farmacologia , Piribedil/farmacologia , Prolactina/metabolismo , Adulto , Ensaios Clínicos como Assunto , Depressão Química , Feminino , Humanos , Estimulação Física , Período Pós-Parto , Gravidez , Prolactina/sangueAssuntos
Ergolinas/uso terapêutico , Galactorreia/tratamento farmacológico , Transtornos da Lactação/tratamento farmacológico , Lactação/efeitos dos fármacos , Metergolina/uso terapêutico , Prolactina/metabolismo , Transtornos Puerperais/tratamento farmacológico , Adulto , Feminino , Humanos , GravidezRESUMO
Ten women were studied during the first post-partum week. Mechanical breast emptying with a breast pump for 30 min induced a marked increase in plasma prolactin (PRL) reaching a maximum 30 min after the beginning of stimulation. In all patients oral administration of the antiserotonin agent metergoline, 8 mg daily for two days, completely blocked any PRL secretion induced by breast stimulation. These results confirm the inhibitory effect of metergoline on PRL release.
Assuntos
Ergolinas/farmacologia , Lactação , Metergolina/farmacologia , Prolactina/sangue , Adulto , Mama , Feminino , Humanos , Estimulação Física , Placebos , GravidezRESUMO
PIP: 11 patients suffering from amenorrhea-galactorrhea, and 26 puerperas for whom lactation was not indicated were treated with 2-Br-alpha-ergocryptine. The drug led to a regression of galactorrhea, and to normal menstrual cycles in all patients, except in one who was suffering from hypophyseal adenoma. Lactation was effectively inhibited in all 26 puerperas after only a few days of treatment. Results showed that 2-Br-alpha-ergocryptine has a powerful inhibitory action on the hypophyseal secretion of prolactin, both during puerperium and in nonpuerperal conditions.^ieng
