1.
Bioorg Med Chem Lett
; 14(16): 4253-6, 2004 Aug 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15261281
RESUMO
A series of novel phenolic antioxidants of amphiphilic structure has been synthesized. Investigations into the influence of aliphatic spacer length and nature of a hydrophilic anchor on the antioxidant activity allowed elucidating certain structure requirements for the membrane-addressed antioxidant designing.
Assuntos
Alcanos/química , Alcanos/farmacologia , Antioxidantes/química , Antioxidantes/farmacologia , Estrutura Molecular , Relação Estrutura-Atividade
2.
Bioorg Med Chem Lett
; 13(6): 1179-82, 2003 Mar 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12643938
RESUMO
Based on the membrane addressing concept, designing and synthesis of 11-(3,5-di-tert-butyl-2-hydroxyphenylcarbamoyl)undecanoic acid have been carried out. Antioxidant properties of the prepared compound were investigated in comparison with its non-amphiphilic analogues.