1.
Bioorg Med Chem Lett
; 11(18): 2469-73, 2001 Sep 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11549449
RESUMO
Structure-activity relationship studies directed toward the optimization of (2S)-2-(3-chlorophenyl)-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-[4-(substituted)piperidin-1-yl]butanes as CCR5 antagonists resulted in the synthesis of the spiro-indanone derivative 8c (IC50=5 nM). These and previous results are summarized in a proposed pharmacophore model for this class of CCR5 antagonist.