[The effect of the carbohydrate ration and physical loading on superoxide dismutase activity and on the diene conjugate concentration of the blood and skeletal muscle cytosol in rats]. / Vliianie uglevodnogo ratsiona i fizicheskoi nagruzki na aktivnost' superoksiddismutazy i kontsentratsiiu dienovykh kon''iugatov v krovi i tsitozole skeletnoi myshtsy krys.

Carbohydrate diet (CD) increased the superoxide dismutase (SOD) activity in the blood and skeletal muscles of rats, while decreasing the diene levels in the blood serum and cytosols. Physical training normalised these alterations to a considerable extent. The CD seems to activate the lipid peroxidation.

[Effect of verapamil and anesthetics on the level of sodium and potassium ions in frog muscles. Role of hydrophobic interactions]. / Vliianie verapamila i anestetikov na soderzhanie ionov natriia i kaliia v myshtsakh liagushki. Rol' gidrofobnykh vzaimodeistvii.

Verapamil, general and local anesthetics influences on ionic contents of frog sartorius and cardiac muscles in respect with these drugs hydrophobicity were studied to clarify the role of verapamil hydrophobic interactions in its physiological activity. It was found that concentration thresholds of the agents toxicities were linearly linked with their hydrophobicity (in logarithmic scale). This relationship provides support for our conclusion that verapamil, general and some local anesthetics are the members of a single drug family. It is a reason to believe that a hydrophobic mechanism of general anesthetic action on cellular structure is the same as a mechanism of verapamil activity in muscles. It is possible that verapamil is accepted as medical drug exactly due to optimum combination of high verapamil hydrophobicity with its structural complementarity to receptor site responsible for use-dependent channel blocking.