RESUMO
The incidence of p53 (C72G) and p21 (C31A) proapoptotic polymorphisms is studied in Russian and Buryat population of Transbaicalian region and prognostic value of these polymorphisms in development of primary open-angle glaucoma (POAG) is assessed. Significant difference in incidence of p53 and p21 was found between healthy subjects and glaucoma patients in both ethnic groups. The incidence of C and G variants of p53-gene and C and A variants of p21-gene differ in glaucoma patients and healthy subjects. The study lets us propose that p53 (C72G) and p27 (C31A) polymorphisms contribute to the risk of POAG onset in Russian and Buryat population as well.
Assuntos
Inibidor de Quinase Dependente de Ciclina p21/genética , Predisposição Genética para Doença/etnologia , Glaucoma de Ângulo Aberto , Polimorfismo de Nucleotídeo Único , Proteína Supressora de Tumor p53/genética , Povo Asiático/genética , Feminino , Frequência do Gene , Glaucoma de Ângulo Aberto/etnologia , Glaucoma de Ângulo Aberto/genética , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Análise de Sequência de DNA , Sibéria/epidemiologiaRESUMO
The efficacy of 1% emoxipin solution (eye drops) in the nonproliferative stage of diabetic retinopathy was studied. The inhibition of lipid peroxidation and an enhancement of antioxidizing guard were observed both after the therapy by the above preparation and 3 months later. It was concluded that emoxipin was effective for leveling the biochemical violations in the "lipid peroxidation--antioxidants" system of lachrymal fluid in patients with the nonproliferative stage of diabetic retinopathy. The prescription of emoxipin eye drops can enhance the efficacy of therapy at the early stages of the disease.
