[Use of a nebulizer as a new method of drug administration in treating dyspnea attacks in patients with bronchial asthma]. / Ispol'zovanie nebulaizera kak novogo metoda dostavki lekarstvennykh preparatov dlia kupirovaniia pristupov udush'ia u bol'nykh bronkhial'noi astmoi.

AIM: To try nebulizer for delivery of berodual solution to cope with asphyxia attacks in bronchial asthma (BA) patients. MATERIALS AND METHODS: Nebulizer was used in 86 patients suffering from bronchial asthma (BA) of different severity treated with standard therapy. Berodual inhalations (1 ml solution) were performed by means of nebulizer Pari Boy. Heart rate, respiratory movements rate, peak flowmetry were evaluated before and after the inhalations. RESULTS: One inhalation was enough for arrest of asphyxia in 70 patients (81.4%), two inhalations relieved the attack in 9 patients (10.46%), 7 patients (8.14%) needed intravenous infusion of euphylline solution for a complete attack arrest. Side effects were not registered. CONCLUSION: Berodual solution inhalations via nebulizer proved clinically and cost effective.

[The cholesterol esterase activity of the blood monocytes and alveolar macrophages in patients with chronic bronchitis]. / Aktivnost kholesterinésterazy monotsitov krovi i al'veoliarnykh makrofagovu bol'nykh khronicheskim bronkhitom.

The activity of cholesterol esterase (CE) in blood monocytes and alveolar macrophages (AMF) of bronchoalveolar fluid (BAF) according to Brecher et al., cell composition of endobronchial cytogram were investigated in 32 patients with chronic bronchitis (CB) and control subjects. In CB sufferers CE activity in AMF was inhibited, while in monocytes it was elevated reaching maximal values in purulent bronchopulmonary CB. Determination of CE activity in AMF and peripheral blood monocytes in CB may serve an additional diagnostic indicator of impaired lipid metabolism and suggests new approaches to investigation of CB pathogenesis.

[Platelet aggregation inhibitors in the comprehensive treatment of bronchial asthma]. / Primenenie dezagregantov v kompleksnoi terapii bronkhial'noi astmy.

Platelet aggregation in infectious bronchial asthma patients was examined in vitro and in vivo upon administration of disaggregation agents trental, curantyl, sermion. A significant disaggregation related to trental and sermion action was recorded in vitro and in vivo as shown by hemolysate-aggregation test, ADP-induces aggregation, plasma levels of the platelet factor IV. Introduction of disaggregation agents in to combined therapy of infectious bronchial asthma contributes to more rapid arrest of bronchoconstriction in relevant patients.

[Tobacco smoking and nonspecific lung diseases]. / Tabakokurenie i nespetsificheskie zabolevaniia legkikh.

The data obtained by the authors indicate that the relationship between chronic nonspecific pulmonary diseases (CNPD) was only found in men and was established to be particularly dependent on the age, onset and duration of tobacco smoking. In men, the relationship manifested itself in the fact that with age and increase of the period of tobacco smoking the risk for pulmonary diseases rose. In women, such relationship appeared immaterial, but they also demonstrated a tendency towards the growth of the CNPD incidence with the rise of the period of tobacco smoking.

[Organization of detection of patients with nonspecific diseases of the lung and their ambulatory care]. / Organizatsiia vyiavleniia bol'nykh nespetsificheskimi zabolevaniiami legkikh i dinamicheskogo dispansernogo nabliudeniia za nimi.

The rate of nonspecific diseases of the lungs among urban and rural population of the Novosibirsk Region was studied by using two-stage screening. It was shown that the number of tuberculous patients per 100,000 adults in the Region as a whole was in 1985-1987 the following: 860.0-1497.0 persons with chronic bronchitis and 170.0-187.0 persons with bronchial asthma. An increase in the number of the persons with chronic bronchitis and bronchial asthma among the inhabitants of both Novosibirsk and the Region was stated. On the basis of these data a scheme for differential dispensary observation was developed. The scheme includes combined prophylactic and treatment programs. The developed organizational grounds for the prophylaxis, early detection and treatment promoted a decrease in primary invalidism due to nonspecific respiratory diseases among the inhabitants of Novosibirsk from 2.2 per 10,000 workers in 1985 to 1.6 in 1987. The respective figures for the inhabitants of the Region were 4.7 and 3.9.

[Nonspecific lung diseases among the population of Western Siberia]. / Nespetsificheskie zabolevaniia legkikh u zhitelei Zapadnoi Sibiri.

Epidemiological surveys conducted in the city of Novosibirsk and the Novosibirsk region in 1980-1986, revealed a high though unequal prevalence of nonspecific pulmonary diseases among different age, sex and occupational groups of the urban and rural population. Chronic bronchitis ranked first in the structure of chronic nonspecific pulmonary diseases. ARVI and recurrent acute pneumonia, unfavorable working conditions and harmful habits influenced the development of chronic bronchitis. The introduction of a 5-group system of dynamic dispensary observation was conductive to a 2.5-3-fold decrease in temporary disability caused by diseases of the respiratory organs preventing a considerable economic loss.

[Immediate and late results of rehabilitation at the climatic health resorts on the southern coast of the Crimea with sunlight- and meteorolabile patients with chronic bronchitis]. / Blizhaishie i otdalennye rezul'taty reabilitatsii na klimaticheskikh kurortakh Iuzhnogo berega Kryma geliometeolabil'nykh bol'nykh khronicheskim bronkhitom.

A study of the social, socioeconomic and economic indices of rehabilitation of patients with chronic obstructive and nonobstructive bronchitis has shown that one should take account of a degree of expression of heliometeolability when selecting patients with chronic bronchitis residing in West Siberia for climatic treatment in the Crimean South Coast. It has been shown that rehabilitation in the Crimean South Coast health resort area is advisable for heliometeostable patients and patients with mild and marked degrees of heliometeolability. Patients with chronic bronchitis should not be sent to the Crimea in winter and late autumn as the rehabilitation effect in this period is lowered.