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CONTEXT: Chemical injury to eyes causes limbal stem cell deficiency (LSCD), which leads to conjunctival epithelium and underlying stromal changes. Simple limbal epithelial transplant helps to restore corneal epithelium and corneal stromal clarity. These changes are documented in this prospective eye study. PURPOSE: To report the changes in epithelial/stromal (E/S) reflectivity ratio and corneal stromal densitometry following simple limbal epithelial transplantation (SLET) in patients with unilateral chemical burn-induced LSCD. METHODS AND MATERIAL: It is a prospective imaging study of cornea before and after SLET. Corneal densitometry with Pentacam and epithelial and stromal reflectivity on anterior segment optical coherence tomography were analyzed for five patients (n = 5 eyes), who underwent autologous SLET for unilateral chemical burn-induced LSCD. STATISTICAL ANALYSIS USED: Mann-Whitney U-test and Pearson correlation. RESULTS: A significant improvement in E/S reflectivity was noted at 1 month (P < 0.05) after SLET, and this was maintained until the end of 6 months. The densitometry measurements decreased in the entire cornea at every level, that is, anterior, central, and posterior cornea. However, the values did not normalize till the last follow-up at 6 months. CONCLUSIONS: A trend of normal corneal epithelization exists in eyes undergoing SLET. Densitometry at all the levels, the anterior, central, and posterior cornea, also decreases after SLET. SLET improves visual outcomes in LSCD eyes not only by epithelization but also by reducing stromal scarring.
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In recent years, significant advances in tissue engineering and regenerative medicine have led to innovative approaches in addressing the various challenges associated with corneal transplants using bioengineered corneas. This mini-review aims to introduce the general ophthalmologist to the concept and technique of bioengineered cornea and provide an overview of the developments so far and an insight into the future direction. By summarizing the latest research and current limitations, we aim to highlight their potential for the future in ultimately contributing to vision restoration.
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Transplante de Córnea , Regeneração , Humanos , Córnea/cirurgia , Engenharia Tecidual/métodos , BioengenhariaAssuntos
Ambliopia/diagnóstico , Córnea/patologia , Topografia da Córnea/métodos , Erros de Diagnóstico , Ceratocone/diagnóstico , Acuidade Visual , Adolescente , Criança , Colágeno/farmacologia , Lentes de Contato , Reagentes de Ligações Cruzadas/farmacologia , Feminino , Humanos , Ceratocone/terapia , MasculinoAssuntos
Cápsula do Cristalino/patologia , Doenças do Cristalino/diagnóstico , Nefrite Hereditária/complicações , Tomografia de Coerência Óptica/métodos , Criança , Humanos , Cápsula do Cristalino/cirurgia , Doenças do Cristalino/etiologia , Doenças do Cristalino/cirurgia , Masculino , Facoemulsificação/métodos , Ruptura Espontânea , Acuidade VisualRESUMO
The peripheral corneal thinning disorders are associated with degenerative, autoimmune, or infective causes. Corneal thinning can subsequently affect the visual acuity either by inducing severe astigmatism or by progressive involvement of the central cornea. In addition to this, the integrity of the eye is at risk. Medical management is necessary to address the underlying inflammatory or infectious causes; however, most of the cases require surgical intervention for tectonic support or for visual rehabilitation in patients with severe astigmatism. Preoperative investigations help in mapping the corneal curvature and thickness, thereby facilitating planning of treatment. Routine corneal transplantation techniques do not yield good results in peripheral corneal thinning disorders. Various surgical modifications have been described to manage these challenging cases. We review the available literature on causes and management of peripheral corneal thinning disorders.
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Córnea/cirurgia , Doenças da Córnea/cirurgia , Procedimentos Cirúrgicos Oftalmológicos/métodos , Acuidade Visual , Córnea/patologia , Doenças da Córnea/diagnóstico , Topografia da Córnea , HumanosRESUMO
Retinal astrocytoma is an important ocular finding for diagnosis of tuberous sclerosis complex and is also an association of neurofibromatosis. The authors present findings of a case of acquired astrocytoma associated with myelinated retinal nerve fibers. The authors also discuss the images and possible cause-effect relationship between them. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:441-442.].