RESUMO
BACKGROUND: Although the concordance between cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers and amyloid-PET findings is well known, there are no data regarding the concordance of amyloid-PET with inconclusive CSF values of amyloid-ß (Aß)1 - 42 and p-tau for the diagnosis of AD. OBJECTIVE: To investigate the relationship between the amyloid-PET results with discordant AD biomarkers values in CSF (Aß1 - 42+/p-tau-or Aß1 - 42-/p-tau+). METHODS: An observational retrospective study, including 62 patients with mild cognitive impairment (32/62) or dementia (30/62), suspicious of AD who had undergone a lumbar puncture to determine CSF AD biomarkers, and presented discordant values in CSF between Aß1 - 42 and p-tau (Aß1 - 42+/p-tau-or Aß1 - 42-/p-tau+). All of them, underwent an amyloid-PET with 18F-Florbetaben. An extensive neuropsychological testing as part of their diagnostic process (MMSE and TMA-93), was performed, and it was also obtained the Global Deterioration Scale. RESULTS: Comparing the discordant CSF results of each patient with the cerebral amyloid-PET results, we found that in the group with Aß1 - 42+ and p-tau-CSF values, the amyloid-PET was positive in 51.2% and negative in 48.8% of patients, while in the group with Aß1 - 42-and p-Tau+ CSF values, the amyloid-PET was positive in 52.6% of patients and negative in 47.4% of them. No significant association was found (pâ=â0.951) between the results of amyloid-PET and the two divergent groups in CSF. CONCLUSIONS: No significant relationship was observed between the results of discordant AD biomarkers in CSF and the result of amyloid-PET. No trend in amyloid-PET results was observed in relation to CSF biomarker values.
Assuntos
Doença de Alzheimer , Disfunção Cognitiva , Humanos , Doença de Alzheimer/diagnóstico , Proteínas tau/líquido cefalorraquidiano , Estudos Retrospectivos , Peptídeos beta-Amiloides/líquido cefalorraquidiano , Disfunção Cognitiva/diagnóstico por imagem , Disfunção Cognitiva/líquido cefalorraquidiano , Tomografia por Emissão de Pósitrons , Biomarcadores/líquido cefalorraquidiano , Fragmentos de Peptídeos/líquido cefalorraquidianoRESUMO
â¢HaNDL syndrome may be a condition probably underdiagnosed in pediatric age.â¢A differential diagnosis with viral, vascular or autoimmune etiology is necessary.â¢Epileptiform alterations in EEG could be possible in this infrequent syndrome.â¢99mTc-HMPAO SPECT provides a potential role in the differential diagnostic and management.
RESUMO
No disponible
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Vasculite/diagnóstico por imagem , Vasculite/tratamento farmacológico , Fluordesoxiglucose F18/administração & dosagem , Febre de Causa Desconhecida/complicações , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Febre de Causa Desconhecida/etiologia , Astenia/etiologia , Corticosteroides/administração & dosagemAssuntos
Febre de Causa Desconhecida/etiologia , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Vasculite/diagnóstico por imagem , Corticosteroides/uso terapêutico , Radioisótopos de Flúor , Fluordesoxiglucose F18 , Humanos , Masculino , Pessoa de Meia-Idade , Compostos Radiofarmacêuticos , Sensibilidade e Especificidade , Vasculite/complicações , Vasculite/tratamento farmacológicoRESUMO
No disponible