RESUMO
Total of 62 patients have been examined, out of which 34 patients had chronic catarrhal rhinitis, and 28 patients - perennial allergic rhinitis. It has been established that intranasal aerosol-therapy with cyclopheron induced expressed improvement of bronchial permeability in these patients, as well as increase of reserve possibilities of lungs and decrease, up to complete elimination, of arterial and venous hypoxemia. Above positive shifts were significant in chronic catarrhal rhinitis.
Assuntos
Acridinas/efeitos adversos , Indutores de Interferon/efeitos adversos , Transtornos Respiratórios/tratamento farmacológico , Rinite Alérgica Perene/tratamento farmacológico , Acridinas/uso terapêutico , Administração por Inalação , Administração Intranasal , Humanos , Capacidade Inspiratória/efeitos dos fármacos , Indutores de Interferon/uso terapêutico , Transtornos Respiratórios/epidemiologia , Rinite Alérgica Perene/epidemiologiaRESUMO
Recently the number of patients with nasal cavity diseases has significantly increased mainly due to the chronic rhinitis. Due to the topical nature of the problem it is necessary to develop new methods of the treatment of chronic rhinitis and to use physiotherapeutic factors which have no side effects of chemotherapy. Total of 62 patients were investigated. 34 of these patients had chronic catarrhal rhinitis and 24 had chronic allergic rhinitis. It has been established that aerosol-therapy with cyclopheron has a considerable effect in patients with these forms of chronic rhinitis, right up to full normalization of their condition as well as on rhinoscopic data, particularly on the olfactory function and mucociliar clearance. Decrease of neutrophiles and eosinophiles present in the mucous discharged from the nasal cavity has a bacteriostatic action expressing in the decrease of size of colonies of microbial cultures.
Assuntos
Acridinas/uso terapêutico , Indutores de Interferon/uso terapêutico , Hipersensibilidade Respiratória/tratamento farmacológico , Rinite Atrófica/tratamento farmacológico , Acridinas/administração & dosagem , Administração por Inalação , Adolescente , Adulto , Aerossóis , Doença Crônica , Feminino , Humanos , Indutores de Interferon/administração & dosagem , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
High prevalence of chronic rhinitis makes more topical the problem of search of new, more effective means of treatment of these pathologies with the establishment of pathogenic mechanisms of the action of these means. Total of 62 patients were investigated. 34 of these patients had chronic catarrhal rhinitis and 28 - chronic allergic rhinitis. It has been established that the use of cyclopheron in aerosol-therapy increases the cortisol discharge from the blood of the patients with rhinitis. It decreases up to the disappearance the inflammatory process in nasal mucus, which strengthens cellular immunity, has a desensitization action, increases non-specific resistance of the organism and has a normalizing action on the indices of humoral immunity. The above shown positive shifts were more pronounced in chronic catarrhal rhinitis.
