[Functional state of thrombocytes in Yersinia infection]. / Funktsional'noe sostoianie trombotsitov pri iersinioznoi infektsii.

As many as 94 patients with yersiniosis were examined for the morphofunctional status of platelets (aggregation, disaggregation, endo-exocytosis and platelet forms). The data indicate that platelet from patients with yersiniosis possess a high ability for aggregation and a low ability for disaggregation. According to the experimental and clinical data, emoxipine can restore disturbed function of human platelets.

[Effect of bacterial toxins on microcirculation (experimental research)]. / Vliianie bakterial'nykh toksinov na mikrogemotsirkuliatsiiu (éksperimental'noe issledovanie).

Histological and biomicroscopic methods were used to study the effects of toxic lemic and meningococcal microbial fractions on mesenteric blood microcirculation in rats. Aggregation ability of red blood cells and thrombocytes was investigated. The sublethal dose of meningococcal toxins was shown to induce marked impairment in the blood microcirculation 30 minutes after intravenous administration. The lethal dose of lemic toxins manifests itself later (in 2-4 hours). Meningococcal toxins are characterized by the increase in the aggregation ability of erythrocytes and thrombocytes in initial observation periods; lemic toxins increase the thrombocyte aggregation and produce almost no effect on erythrocyte aggregation.

[Various characteristics of the thrombohemorrhagic syndrome in a generalized form of meningococcal infection complicated by toxic-infectious shock]. / Nekotorye osobennosti trombogemorragicheskogo sindroma pri generalizovannoi forme meningokokkovoi infektsii, oslozhnennoi toksiko-infektsionnym shokom.

Blood coagulation was studied in 19 patients with generalized meningococcal infection complicated by toxico-infectious shock (TIS). The outcomes were fatal in 42% of cases. Blood coagulation studies were done on days 1, 2, 3, 5-7 and 19-21 of treatment. Blood coagulability was found to be reduced drastically at the peak of disease: platelet aggregability was depressed substantially, and platelet secretory function showed profound disorders. The recovery of both plasma and platelet parameters of blood coagulation was rather slow. The magnitude of disorders may have a predictive value for the prognosis of the disease.

[Study of platelet function by quantitative determination of the fluorescence intensity of 5HT-organelles]. / Izuchenie funktsii trombotsitov metodom kolichestvennogo opredeleniia intensivnosti fliuorestsentsii 5HT-organell.

Assay of the fluorescence intensity of 5HT-organelles was performed to examine the functional properties of platelets from patients with meningococcal infection. Platelets were found to have a higher capacity for endocytosis at the height of the disease, tending to its normalization with treatment and convalescence. Incubation of donor's plasma rich in platelets with meningococcal lipopolysaccharide was discovered to lead to an appreciable increase in the absorption capacity of platelets. It is suggested that endotoxinemia is one of the factors responsible for the impairment of platelet function.