RESUMO
BACKGROUND: NCCN Guidelines recommend screening young women with an increased breast cancer risk (>20 â% lifetime risk). We sought to evaluate our institutional rates of high-risk screening in young breast cancer patients prior to their diagnoses." METHODS: A single-institution retrospective review (2013-2018) was performed investigating risk scores (Tyrer-Cuzick model) and characteristics of breast cancer patients (age <40 ây) prior to diagnosis. RESULTS: 92 breast cancer patients age <40 ây were identified (average age 34.5). Only 3.3 â% (n â= â3) underwent appropriate screening, despite 35.8 â% meeting high-risk criteria. Nearly all patients underwent genetic testing (98.9 â%) with pathogenic mutations identified in 36.5 â%, including 15.3 â% with BRCA1/2 mutations. CONCLUSIONS: This analysis highlights a significant discrepancy between those meeting criteria for high-risk screening and those who underwent appropriate screening. We identified that this cohort carries significant genetic burden. Future analysis should investigate these findings on a broader scale and strategies to improve screening.
