1.
Drug Chem Toxicol
; 30(1): 67-81, 2007.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17364865
RESUMO
The DNA damage in bone marrow cells induced by etoposide (E) injected intraperitoneally to rats (100 mg/kg b.w.) decreased to the control level when quercetin (Q) was administered subcutaneously for 10 consecutive days (40 mg/kg b.w.per day) before E was injected. The antioxidant power (FRAP assay) increased significantly after Q or E compared with control rats but did not change when Q preceded the E injection. The superoxide dismutase activity significantly increased in Q+E-treated rats compared with quercetin given alone. The study provides evidence that Q protects bone marrow cells against long-lived E-induced DNA damage and alters the redox balance in lung tissue.
Assuntos
Células da Medula Óssea/efeitos dos fármacos , Dano ao DNA/efeitos dos fármacos , Etoposídeo/toxicidade , Quercetina/farmacologia , Animais , Catalase/metabolismo , Ensaio Cometa , Feminino , Recuperação de Fluorescência Após Fotodegradação , Injeções Subcutâneas , Modelos Lineares , Pulmão/metabolismo , Quercetina/administração & dosagem , Ratos , Ratos Wistar , Superóxido Dismutase/metabolismo
2.
Nature
; 424(6948): 487, 2003 Jul 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12891329