RESUMO
This article has been retracted at the request of the Editor. After a thorough investigation the Editor-in-Chief has retracted this article as it showed evidence of substantial manipulation of the peer review.
RESUMO
Ahead of Print article withdrawn by publisher.
Assuntos
Cancro/complicações , Infecções por HIV/complicações , Sífilis/complicações , Treponema pallidum/isolamento & purificação , Adulto , Feminino , Gangrena , Infecções por HIV/tratamento farmacológico , Humanos , Injeções Intramusculares , Penicilina G/uso terapêutico , Sífilis/tratamento farmacológico , Resultado do TratamentoRESUMO
Immunohistochemical analysis was used to study depigmented skin areas such as macular of depigmentation and skin perimakular areas in vitiligo patients. It has been shown that the cells containing melanocytic cell marker TRP1 are localized both in macular and perimakular areas. Within the macula of depigmentation all TRP1 positive cells are in close contact with the basement membrane. In perimakular areas many cells that have lost contact with the basement membrane, were localized deep in the epidermis. About 92 % of TRP1 positive perimakular cells were also vimentin positive. Vimentin positive cells were numerous in perimakular areas but missing in the macula of depigmentation. Dense groups of cells immunopositive for transcription factor Snail, known as inductor of epithelial-mesenchymal transition, were localized in perimakular areas in close proximity to the macula depigmentation border. Such cells were extremely rare within the macula of depigmentation. There is reason to assume that an intensive process, which is similar to the epithelial-mesenchymal transition, might be the cause of melanocyte death in perimakular field, and thus prevents repigmentation of depigmented areas.
Assuntos
Transição Epitelial-Mesenquimal , Melanócitos , Pigmentação da Pele , Pele , Vitiligo , Antígenos de Diferenciação/metabolismo , Biomarcadores/metabolismo , Feminino , Humanos , Imuno-Histoquímica , Masculino , Melanócitos/metabolismo , Melanócitos/patologia , Pele/metabolismo , Pele/patologia , Fatores de Transcrição da Família Snail/metabolismo , Tripsina/metabolismo , Vimentina/metabolismo , Vitiligo/metabolismo , Vitiligo/patologiaAssuntos
Padrões de Prática Médica , Sorodiagnóstico da Sífilis/métodos , Sífilis/microbiologia , Treponema pallidum/isolamento & purificação , Antitreponêmicos/administração & dosagem , Antitreponêmicos/uso terapêutico , Diagnóstico Diferencial , Reações Falso-Negativas , Reações Falso-Positivas , Humanos , Sensibilidade e Especificidade , Sífilis/tratamento farmacológico , Treponema pallidum/efeitos dos fármacosRESUMO
A total of 106 patients with lichen planus were examined for proliferative activity of peripheral blood lymphocytes and exogenous interleukin-2 effect on recovery of cyclosporin A suppressed proliferative response to mitogen. Lymphocyte proliferative activity was assessed by the level of 3H thymidine incorporation in cellular DNA. This parameter was found reduced in patients with lichen planus in comparison with healthy donors and dependent on the disease stage but not degree of dissemination. No disorders were detected in lymphocyte capacity to express receptors for interleukin-2 in the course of their activation. Tigason, prednisolone, and delagil had a marked in vitro antiproliferative effect on the lymphocytes of patients with lichen planus, tigason exerting the highest effect and prednisolone the lowest.
