Functional activities of the amygdala: an overview.

Research to date into the amygdala shows that it has an integrative role in behavioural, vegetative and endocrine activities of animals in their relation with their environment. Animal studies show that amygdala has a role in emotional response, integrating input signals and initiating activities related to them. Different nuclei seem to have different effects. A complete picture of the functional roles of the amygdala is unavailable, and it has been suggested that the amygdala is functionally and anatomically heterogeneous. Amygdaloid subnuclei appear to have a role in the modulation of fear, in memory and attention, and in some sexual and sex-related behaviour of rats. In humans, functional magnetic resonance imaging shows that the amygdala responds preferentially to emotionally charged stimuli. Bilateral amygdala damage in humans can compromise the recognition of fear in facial expressions, an important ability in social judgement. Future study of the amygdala promises to shed light on emotional disorders in humans.

Effects of gonadal hormones on the morphology of neurons from the medial amygdaloid nucleus of rats.

The medial amygdala (MeA) has receptors for gonadal hormones and is a sexually dimorphic area in rats. The aims of the present work were (1) to look at sex differences and the effect of gonadal hormone withdrawal in males castrated as offspring or at adulthood on neuronal soma area in the anterior and posterior MeA and (2) to study the dendritic branching and the density of dendritic spines in neurons from the MeA of intact males and females. Animals were adult rats, for which the single-section Golgi method was used. Stellate and bitufted cells were found in the MeA. Comparing data among groups, no significant difference in cell body area was found. Dendrites divide sparingly and have very different lengths, and a statistical difference (p < 0.001, males higher than females) in the spine density in the anterior MeA, but not in the posterior MeA, was found. These results suggest that castration does not alter the somal area in males submitted to gonadectomy during the early postnatal period or at adulthood. In addition, the already described sex difference in this nucleus may be more related to the neuropil than the neuronal somal area, which may be relevant for the function of the MeA.

[Use of amitriptyline in attention deficit hyperactivity disorder]. / Uso de amitriptilina na síndrome de hiperatividade com déficit de atenção.

We studied the action of amitriptyline (AMI) in the attention deficit hyperactivity disorder (ADHD). Twenty-five children who came to consultation for ADHD were analyzed, in two groups: the group which used AMI (n = 18) at 1.6 mg/kg/day and the group which used placebo (n = 7). Both groups were submitted to two assessments in a 30 days interval, which consisted of the evolutive neurological evolution examination (ENE) and the WISC scale subtests on numbers, drawings to be completed and the code. The results showed that the AMI produced an improvement in performance in the motor persistence tests.