High-performance towing cable hydrophone array with an improved ultra-sensitive fiber-optic distributed acoustic sensing system.

A high-performance towing cable hydrophone array based on an improved ultra-sensitive fiber-optic distributed acoustic sensing system (uDAS) with picostrain sensitivity is demonstrated and tested in sea trial, for the first time. A new composite transducer is designed and optimized to enhance the acoustic pressure sensitivity significantly. A sea trial is carried out to test the performances of such a hydrophone array, including flow noise, underwater acoustic signal capture capacity, beamforming processing and localization of artificial source targets. The array exhibits high sensitivity and low noise floor. An average sensitivity of -129.23 dB re rad/µPa at frequencies from 10 Hz to 1500 Hz has been achieved. The localization at distances of 5 km and 10 km is realized, respectively, validating the excellent remote detection and positioning capability of the hydrophone system. The proposed towing cable system, with high sensitivity, simple structure and remote target localization ability, may pave a way for development of the next generation of high-performance light-weighting hydrophone arrays for towing applications.

Fiber-Optic Theranostics (FOT): Interstitial Fiber-Optic Needles for Cancer Sensing and Therapy.

Photonics has spurred a myriad of diagnostic and therapeutic applications for defeating cancer owing to its superiority in spatiotemporal maneuverability and minimal harm. The limits of light penetration depth and elusiveness of photosensitizer utilization, however, impede the implementation of the photodiagnostic and -therapy for determining and annihilating the deep-situated tumor. Herein, a promising strategy that harnesses functional optical fibers is developed and demonstrated to realize an in vivo endoscopic cancer sensing and therapy ensemble. Tumor detection is investigated using hypoxia-sensitive fluorescent fibers to realize fast and accurate tumor recognition and diagnosis. The tumor treatment is further performed by exploiting the endogenous photothermal effect of rare-earth-doped optical fibers. The eradication of orthotopic and subcutaneous xenografts significantly validates the availability of tumoricidal fibers. The strategy opens horizons to inspire the design of optical fiber-mediated "plug and play" precise tumor theranostics with high safety, which may intrigue broader fields, such as fiber optics, materials, chemistry, medicine, and clinics.

Harmonic optical microfiber Bragg grating immunosensor for the accelerative test of cardiac biomarker (cTn-I).

Fiber-optic biosensor has shown tremendous promise in probing cardiac biomarkers label-free and in-operando. However, temperature cross-sensitivity is ubiquitously found and impedes further advances of the fiber-optic biosensors, especially for the scenario of rapid test at-body. In this study, we exploit a new regime that harnesses the harmonic resonances of a single microfiber Bragg grating to rule out the impact of the thermal noise. The reflections yielded by the harmonics can be engineered simultaneously at the two overriding optical wavebands, i.e., 1 µm and 1.55 µm, promising a remote acquisition of the sensing signals at patient by virtue of the Yb and/or Er-doped fiber amplifiers which are highly commercial. Furthermore, the functionality of the temperature-offset allows for the understanding of the biomolecular stimulating at the body temperature and thus facilitating the acceleration of the cardiac biomarker test. The proposed proof-of-concept enriches the arsenal of tools for fiber biosensors and enables a vista for the instant and in-vivo diagnosis of acute heart diseases.

Label-Free and Reproducible Chemical Sensor Using the Vertical-Fluid-Array Induced Optical Fiber Long Period Grating (VIOLIN).

Fiber optical refractometers have gained a substantial reputation in biological and chemical sensing domain regarding their label-free and remote-operation working mode. However, the practical breakthrough of the fiber optical bio/chemosensor is impeded by a lack of reconfigurability as well as the explicitness of the determination between bulk and surface refractive indices. In this letter, we further implement the highly flexible and reproducible long period grating called "VIOLIN" in chemical sensing area for the demonstration of moving those obstacles. In this configuration, the liquid is not only leveraged as the chemical carrier but also the periodic modulation of the optical fiber to facilitate the resonant signal. The thiol compound that is adsorbed by the fluidic substrate can be transduced to the pure alteration of the bulk refractive index of the liquid, which can be sensitively perceived by the resonant drift. Taking advantage of its freely dismantled feature, the VIOLIN sensor enables flexible reproduction and high throughput detection, yielding a new vision to the fiber optic biochemical sensing field.

Temperature monitorable refractometer of microfiber Bragg grating using a duet of harmonic resonances.

To overcome the temperature cross-sensitivity of the microfiber Bragg grating (m-FBG) refractometer, we propose a novel refractive-index-temperature dual-sensing paradigm involving the third harmonic Bragg resonance that presents distinctive sensing characteristics. Strong resonances are obtained in both 1060 nm and 1550 nm wavebands under the modulation of the UV Talbot pattern. Moreover, higher-order transverse mode coupled resonance is also observed at the third harmonic waveband, supplementing an independent signal for enabling a sensing trio potentially. It is believed that the proposed dual-sensing paradigm would contribute to the m-FBT-based chemoprobes/bioprobes.