Estudio de las intervenciones farmacéuticas en un hospital universitario / No disponible

Las intervenciones farmacéuticas tienen como objetivo detectar problemas existentes o potenciales relacionados con los medicamentos e intervenir para resolverlos. En el presente trabajo se realizó un estudio prospectivo a fin de cuantificar y clasificar las intervenciones farmacoterapéuticas registradas en un período de 10 semanas. Nuestros resultados muestran que fue elevado (137) el número de problemas relacionados con los medicamentos que se hubieran obviado sin la intervención del farmacéutico. Se observó que el grado de aceptación de las intervenciones totales fue del 85,5%. Estos resultados indican la necesidad de aumentar la integración y establecer relaciones de cooperación con los demás profesionales para poder brindar un mejor servicio dentro del sistema (AU)

The object of the pharmaceutical interventions is to detect the real or potential problems related to drugs and to take part to resolve them. In the present work, it was carried out a prospective study in order to quantify and to classify the registered pharmacotherapeutic interventions in a period of 10 weeks. Our results indicate that the number of problems related to the drugs was high (137) that had been obviated without the intervention of the pharmacist. It was observed that the degree of acceptance of the total interventions was 85,5%. These result indicated the need to increase the integration and to establishing relations of cooperation with the other professionals to be able to offer a better service within the system (AU)

c-erbB 2 serum level as prognostic factor in hormonally treated advanced breast cancer patients.

To investigate whether c-erbB 2 serum levels may be predictive of clinical response, progression-free and overall survival in postmenopausal women with advanced breast cancer hormonally treated, 265 patients enrolled in previous clinical trials were evaluated. C-erbB 2 serum levels were assessed before the start of treatment and in a subgroup of patients also at the first response evaluation. In addition, serum CA 15.3 levels were determined. The role of c-erbB 2 was investigated by means of multiple regression models in which both c-erbB 2 and CA 15.3 values were modelled as continuous variables together with other known prognostic factors. The failure probability tended to be higher in the presence of high c-erbB 2 levels, but the trend was not statistically significant; in contrast, significant results were obtained for progression-free survival (PFS,P <0.001) and overall survival (OS, P=0.014). The within-patient c-erbB 2 variation significantly predicted PFS (P=0.006) and OS (P=0.040). It is worth noting that c-erbB 2 and CA 15.3 baseline levels were significantly correlated and that the prognostic effect of c-erbB 2 tended to disappear in the presence of high CA 15.3 levels for PFS and OS.