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Protein & Cell ; (12): 825-832, 2015.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-757183

RESUMO

How follicular T-helper (Tfh) cells develop is incompletely understood. We find that, upon antigen exposure in vivo, both naïve and antigen-experienced T cells sequentially upregulate CXCR5 and Bcl6 within the first 24 h, relocate to the T-B border, and give rise to phenotypic Bcl6(+)CXCR5(+) Tfh cells before the first cell division. CXCR5 upregulation is more dependent on ICOS costimulation than that of Bcl6, and early Bcl6 induction requires T-cell expression of CXCR5 and, presumably, relocation toward the follicle. This early and rapid upregulation of CXCR5 and Bcl6 depends on IL-6 produced by radiation-resistant cells. These results suggest that a Bcl6(hi)CXCR5(hi) phenotype does not automatically define a Tfh lineage but might reflect a state of antigen exposure and non-commitment to terminal effector fates and that niches in the T-B border and/or the follicle are important for optimal Bcl6 induction and maintenance.


Assuntos
Animais , Camundongos , Ligante de CD40 , Metabolismo , Diferenciação Celular , Fisiologia , Proteínas de Ligação a DNA , Metabolismo , Proteína Coestimuladora de Linfócitos T Induzíveis , Metabolismo , Interleucina-6 , Metabolismo , Proteínas Proto-Oncogênicas c-bcl-6 , Receptores CXCR5 , Metabolismo , Linfócitos T Auxiliares-Indutores , Metabolismo
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