RESUMO
Peritoneal adhesion is one of the common complications of abdominal and pelvic operations,the impact of which is immense in terms of human suffering and substantial socio-economic burden.There is an urgent need for a more effective understanding of the disease process and its etiology,to evaluate the pharmacologic,mechanical,and surgical adjuvant strategies to minimize peritoneal adhesion formation.
RESUMO
Tumor invasion and metastasis are regarded as main reasons for the failure of therpy and the reason of patients death.The mechnism of tumor metastasis is still uncertain.The pre-metastatic niche hypothesis provides us with new ideas to discover the mechnism.Numerous materials are involved in the formation of the pre-metastatic niche according to this hypothesis,including bone marrow-derived cells,microvesicles,exosomes,CD44,and so on.A further research on this hypothesis helps to deeply understand the nature of metastasis and leads clinical doctors to explore novel targets for clinical diagnoses and therapies.
