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Mol Biol (Mosk) ; 44(1): 140-51, 2010.
Artigo em Russo | MEDLINE | ID: mdl-20198868

RESUMO

We performed a large-scale search for attenuation regulation in bacteria based on two original computer programs modeling attenuation regulation and multiple alignment along a phylogenetic tree. The programs are available from http://lab6.iitp.ru. Candidate attenuations are predicted in many bacteria from alpha-, beta-, gamma-, delta-proteobacteria, Actinobacteria, Bacteroidetes/Chlorobi, Firmicutes and Thermotogae; in Cloroflexi--upstream genes hisG, hisZ, hisS, pheA, pheST, trpEG, trpA, trpB, trpE, trpS, thrA, thrS, leuA, leuS, ilvB, ilvI, ilvA, ilvC, ilvD, ilvG. Other bacterial taxa were not predicted to have attenuation; searches were conducted across all bacterial genomes contained in GenBank, NCBI. Evolution of attenuation is discussed.


Assuntos
Aminoácidos/biossíntese , Bactérias/genética , Regulação Bacteriana da Expressão Gênica , Óperon , RNA Mensageiro/genética , Algoritmos , Aminoácidos/genética , Sequência de Bases , Genômica , Análise de Sequência de RNA , Software
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