1.
Org Lett
; 26(30): 6491-6496, 2024 Aug 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-39023907
RESUMO
γ-Keto acid is a valuable chemical motif in a wide range of fields including organic, biological, and medicinal chemistry. However, its single-step synthesis is challenging because of the mismatch of the carbonyl polarity and low tolerance of carboxylic acids. Herein, we report the single-step syntheses of γ-keto acids using alkenes and CO2. Our photocatalytic system enabled the transformation of alkenes under mild conditions in high yields (up to 95%) with broad substrate generality (35 examples).