Assuntos
Poluentes Atmosféricos/toxicidade , Feto/efeitos dos fármacos , Anormalidades Induzidas por Medicamentos , Animais , Antraquinonas/toxicidade , Benzeno/toxicidade , Monóxido de Carbono/toxicidade , Desenvolvimento Embrionário e Fetal/efeitos dos fármacos , Feminino , Reabsorção do Feto/induzido quimicamente , Gasolina , Hidrocarbonetos/toxicidade , Gravidez , Ratos , Ratos EndogâmicosRESUMO
In brain medial-basal areas (midbrain, hypothalamus, striatum) ascorbic acid (AA) content is lower than in the rest of the brain. It has been hypothesized that AA may be involved in brain catecholamine metabolism. To test this hypothesis AA content in medial-basal areas and in the remaining brain areas was measured in rats pretreated with alpha-methyl-paratyrosine (alpha-MpT), a tyrosine hydroxylase inhibitor. The AA content, in brain medial-basal areas, had slightly decreased, without statistically significant differences, in rats treated with alpha-MpT in comparison with untreated animals. Therefore the role of AA in brain metabolism is not clear to.
Assuntos
Ácido Ascórbico/metabolismo , Encéfalo/metabolismo , Catecolaminas/biossíntese , Metiltirosinas/farmacologia , Animais , Encéfalo/efeitos dos fármacos , Masculino , Ratos , Ratos Endogâmicos , Tirosina 3-Mono-Oxigenase/antagonistas & inibidores , alfa-MetiltirosinaRESUMO
Streptozotocin (Stz) diabetes was induced in rats to study the changes in glycosylated hemoglobin. An increase of glycosylated hemoglobin had been found since the first days of the experiment. These results suggest that such a model may be used for the study of changes of glycosylated hemoglobin in diabetes.
Assuntos
Diabetes Mellitus Experimental/sangue , Hemoglobinas Glicadas/análise , Animais , Ratos , Ratos EndogâmicosRESUMO
Streptozotocin (Stz) diabetes was induced to study the changes of glycosylated hemoglobin in rats treated with raubasina (R), drug widely used in the vascular compliance of natural human diabetes. Raubasina reduced significantly the increase of glycosylated hemoglobin found in streptozotocin induced diabetes. These results support data obtained in clinical trials.
Assuntos
Diabetes Mellitus Experimental/sangue , Hemoglobinas Glicadas/análise , Alcaloides de Triptamina e Secologanina , Ioimbina/farmacologia , Animais , Ratos , Ratos EndogâmicosAssuntos
Córtex Suprarrenal/metabolismo , Analgésicos Opioides/farmacologia , Corticosterona/metabolismo , Indóis/farmacologia , Sistema Hipófise-Suprarrenal/efeitos dos fármacos , Córtex Suprarrenal/química , Analgésicos Opioides/administração & dosagem , Animais , Ácido Ascórbico/análise , Colesterol/análise , Corticosterona/sangue , Relação Dose-Resposta a Droga , Feminino , Indóis/administração & dosagem , Injeções Intraperitoneais , Masculino , RatosRESUMO
Male albino rats of the Wistar strain, without food from 48 h, have been operated with pylorus ligature and treated with cimetidine, at the dose of 30 mg/kg i.m., just after the operation and 12 h later. Cimetidine reduced the size and the number of gastric ulcers induced by pylorus ligature, showing a significant protective effect. This action, due to the inhibition of gastric secretion induced by cimetidine, supports the hypothesis that the staunching of gastric juice (by pylorus ligature) plays a basic role in the pathogenesis of these experimental gastric ulcers.
Assuntos
Cimetidina/uso terapêutico , Guanidinas/uso terapêutico , Antro Pilórico/fisiologia , Úlcera Gástrica/tratamento farmacológico , Animais , Suco Gástrico/efeitos dos fármacos , Ligadura , Masculino , RatosRESUMO
The effects of cimetidine on experimental stress, induced by a long time fast and pylorus ligature, in male albino rats were investigated. The drug at the dose of 30 mg/kg was administered i.m. just after the operation and 12 h later. To evaluate the interference of cimetidine on the hypothalamo-hypophyseal-adrenal axis were dosed, in the rat, the level of adrenal ascorbic acid and cholesterol as well as corticosterone plasma levels. The results seem to suggest that cimetidine, in this experiment, is unable to modify stress induced changes.
