[Effects of enterosorption on the activity of natural-resistance humoral factors in patients with burns]. / Vliianie énterosorbtsii na aktivnost' gumoral'nykh faktorov estestvennoi rezistentnosti organizma postradavshikh s ozhogami.

The data suggesting the enterosorbent influence on the activity of proteolysis inhibitors and arginase, on the fibrin-fibrinogen and fibronectin decay products content, blood serum toxin fixating activity of injured with the burns were presented. The dependence of expression of mentioned indexes changes from the trauma severity in acute burn disease period was shown. The enterosgel application promotes the lowering of dystrophic degree severity, alike the hepar and fixed macrophage system load, the investigated indexes normalization acceleration, and patients condition improvement.

[Efficacy of the use of a stabilized alpha2-macroglobulin concentrate in experimental burns]. / Effektivnost' primeneniia stabilizirovannoi kompozitsii kontsentrata alpha2-makroglobulina pri ozhogovoi bolezni v éksperimente.

The effectiveness of the use of a stabilized composition of alpha 2-macroglobulin concentrate obtained from fraction III of plasma proteins according to Cohn in burn disease in the experiment on guinea pigs was studied. Under the influence of intraabdominal administration for 4 days of alpha 2-macroglobulin concentrate with a stabilizer, healing of the burn wounds, normalization of a state of the animals occurred 2 times more rapidly than in control ones, activity of acid proteinases restored by day 5 (in control--by day 14) due to increase in activity of proteolytic enzyme inhibitors.

[The effect of antiprotein plasma on humoral resistance in children with severe burns]. / Vliianie antiproteinoi plazmy na gumoral'nuiu reziztentnost' organizma detei s tiazhëlymi ozhogami.

In severely burned children, depending on severity of injury, the anti-triptic activity of blood serum, alpha 2-macroglobulin level, fibronectin, activity of an arginase decrease at the acute period of toxemia and septic toxemia. The content of the products of fibrin-fibrinogen degradation increases considerably. Alteration of the indices studied is of informative value and is associated with dynamics of the toxic syndrome development. Use of donor antiproteic plasma has a positive therapeutic effect.

[Effect of sorption detoxification in severe burns on the development of cell-mediated reactions in the vascular and extravascular phases of inflammation]. / Vliianie sorbtsionnoi detoksikatsii pri tiazhelykh ozhogakh na razvitie kletochno-oposredovannykh reaktsii v sosudistoi i vnesosudistoi fazakh vospaleniia.

In combined use of general and local sorption detoxication in 30 patients with severe burns, the pronounced antiinflammatory action is caused by redistribution of neutrophilic granulocytes with different activity of myeloperoxidase systems, decrease in lesion of a vascular wall and development of the perfect cellular reactions into extravascular phase of inflammation. The area of deep burn wounds reduced 2.8-fold when compared with that in patients, in whom no sorption methods were used.

[Status of the proteinase-protease inhibitor system in patients with pathological scars]. / Sostoianie sistemy proteinazy-ingibitory u bol'nykh s patologi- cheskimi rubtsami.

In patients with pathological scars, especially in children, the activity of proteolytic enzymes (prekallikrein, acid and neutral proteinases) is increased. Summary inhibitory activity and content of the alpha 2-macroglobulin in the serum and scar tissue is also increased. This is indicative of continued inflammation.

[The effect of combined methods of detoxication on the development of inflammatory reactions in severe burns]. / Vliianie sochetannykh metodov dezintoksikatsii na razvitie vospalitel'noi reaktsii pri tiazhelykh ozhogakh.

The development of inflammatory reaction in 106 patients with severe and extremely severe burns in combined use in the complex treatment of extracorporeal hemosorption, enterosorption, applicative sorption by the powdery PMS-Zn sorbent, passive immunotherapy was studied. The modulative effect of the methods of general and local sorptive detoxication on the development of inflammatory reaction of the area of thermal trauma with reduction of damaging effect of proteolytic enzymes and formation of cellular reaction directed at protection from microorganisms and beginning of the proliferative stage of reparative regeneration is shown. Lethality in severe burns was 17.7%, in extremely severe--50.8%.

[The use of silicon organic sorbents for the local treatment of burn wounds]. / Primenenie kremniiorganicheskikh sorbentov dlia mestnogo lecheniia ozhogovykh ran.

The applicative-sorptive method of treatment was used by the authors in 57 patients ranging in age from 18 to 60 years with II-III AB degree burns of 10 to 50% of the body surface. The decrease in activity of proteolytic enzymes in the wound discharge, the increase in the activity of microbicidal systems of neutrophilic leukocytes, and formation of a phagocytic type of local resistance of an organism were noted. The epithelization of II-III A degree burn wounds accelerated, and the area of deep burn wounds reduced in patients.

[Hemosorption detoxication in the treatment of severe burns]. / Gemosorbtsionnaia detoksikatsiia v lechenii tiazheloobozhzhennykh.

The use of hemosorption detoxication at early terms after burn trauma against the background of the intensive infusion-transfusion treatment is an effective method of treatment in the acute period of burn disease. In the total it shortens the period of treatment of critically burned patients.

[Proteolytic enzymes of leukocytes in human blood]. / Issledovanie proteoliticheskikh fermentov leikotsitov krovi cheloveka.

Hydrolysis of various substrates by proteolytic enzymes from human blood leukocytes was studied. Among the protein substrates used protamine was hydrolyzed at the highest rate. Among the synthetic substrates--N-benzoyl-D,L-arginine ethyl ester was the one hydrolyzed most rapidly. Effect of native inhibitors of proteinases and of bivalent metal ions on the proteolytic activity in leukocytes was also studied. The highest proteolytic activity, estimated by hydrolysis of protamine, was found in lysosomal and microsomal fractions.

[Nature of the proteinase activated by the contact factor in human blood plasma]. / Izuchenie prirody proteinazy, aktiviruiushcheisia kontaktnym faktorom, v plazme krovi cheloveka.

The nature of protamine splitting proteinase, which was formed after treatment of human blood plasma by kaolin or silicone (aerosile), was studied. The activated enzyme did not exhibite the properties of thrombin and plasmin in reactions with specific substrates. Kyninogenic, TAME (N-tosyl-d-,l-arginine methyl ester)-esterase and protamine splitting activities were inherent in the proteinase; these properties enabled to group the enzyme with blood kallikreins. The purified preparations of human blood plasma kallikrein hydrolyzed protamine sulphate even at 10 mcg/ml concentration. alpha2-macroglobulin inhibited the protamine splitting activity of the plasma kallikrein.