RESUMO
Review of the literature shows that currently there is an accumulation of data on the genetic determination of individual susceptibility to adverse industrial factors. Material of the research were high molecular DNA samples isolated from epithelial mouth scrapings in 99 foundry workers. Study of polymorphic variants of interleukin genes was performed by means of the analysis ofproducts of amplification of specific regions of the genome. Homozygous genotype TNF-a (-308A/G) was established to increase the relative risk of shaping of chronic respiratory diseases: with AA alleles - by 6.4 times and GG alleles - by 2.4 times, while the heterozygous genotype (AG) decreases - by 1. 9 times. Polymorphism of gene IL-1ß (+3953 T / C) had no significance for the development of respiratory disease. Genotyping interleukins, involved in the inflammatory responses of the bronchopulmonary tract, can be considered as an element ofprimary prevention in industries with a high risk for shaping of respiratory diseases.
Assuntos
Metalurgia , Doenças Profissionais , Doenças Respiratórias , Fator de Necrose Tumoral alfa/genética , Adulto , Predisposição Genética para Doença , Humanos , Hipersensibilidade/genética , Interleucina-1beta/genética , Masculino , Doenças Profissionais/epidemiologia , Doenças Profissionais/etiologia , Doenças Profissionais/genética , Polimorfismo Genético , Doenças Respiratórias/epidemiologia , Doenças Respiratórias/etiologia , Doenças Respiratórias/genética , Federação Russa/epidemiologiaRESUMO
The paper provides the results of assessment of prior and posterior occupational risks and those of questionnaire analysis in foundry shop workers from machinery enterprises. According to the data of attestation of job places, the working conditions of major foundry occupations were ascertained to correspond to class 3, grades 1 to 3. The prior risk for occupational respiratory diseases (RD) was defined as moderate whereas the posterior risk was high. According to the results of a questionnaire survey, more than half of the workers sought medical advice for bronchopulmonary pathology. Determination of whether there is, in terms of the etiological share, a cause-and-effect relationship between RDs and working conditions has shown that the occupation was highly responsible, which suggests that harmful industrial factors make a considerable contribution to the development of RDs in the workers of the enterprises under study.
