[Plasmic activity of phospholipid membranes in nephritis]. / Plazmennaia aktivnost' fosfolipidnykh membran pri nefritakh.

AIM: To study activity of plasmic phospholipid membranes (PPM) in patients with chronic nephritis (CN) as regards clinical-laboratory and morphological characteristics of the disease. MATERIAL AND METHODS: 10 patients with chronic mesangial glomerulonephritis (CMG) and 4 patients with chronic drug-induced tubulointerstitial nephritis were examined. All the patients had moderate arterial hypertension including 5 patients with CMG combined with nephrotic syndrome. 9 patients had elevated blood creatinine (up to 500 mcmol/l). Measurements were made of routine laboratory indices, blood coagulation and paracoagulation, Willebrand's factor (WF), aggregation time (AT), phospholipid activation of blood coagulation (FABC), morphological indices of activity and sclerosis. RESULTS: In spite of chronic latent intravascular blood coagulation, CN was characterized by apparent lowering of FABC which was more evident in CMG. There was a weak correlation between a FABC fall and the level of proteinuria, lipidemia, AT of platelets, indices of activity. Some parallels exist between creatininemia and activity of PPM. A close reverse relationship was found between FABC and WF, and a direct one between FABC and sclerosis index. CONCLUSION: Subnormal PPM activity in CN correlates with organic microthrombi formation and promotes the discussion of both mechanisms of FABC formation disturbances and possible ways of PPM consumption including enhanced diffusion into the mesangium in progressing nephrosclerosis.

[Intensive care of children with DIC syndrome based on the use of low molecular weight heparins]. / Intensifikatsiia terapii DVS-sindroma u detei na osnove primeneniia nizkomolekuliarnykh geparinov.

The first section of this paper presents data on low-molecular-weight heparins: pharmacokinetics and pharmacodynamics, advantages in comparison with common heparin. The second section presents the results of fraxiparin and clivarin use in 43 children aged 9 months to 14 years with acute/subacute DIC syndrome of infectious origin. Therapeutic and maintenance doses, the mode of injection of low-molecular-weight heparins, and methods for laboratory monitoring of their efficiency and safety are presented.

[Role of the hemostatic system in the progression of acute glomerulonephritis]. / Rol' sistemy gemostaza v progressirovanii ostrogo glomerulonefrita.

AIM: To study basic parameters of hemostasis in the course of acute poststreptococcal glomerulonephritis (APSGN). MATERIAL AND METHODS: Platelets number and aggregation 4-platelet factor, Willebrand's factor, activated partial thromboplatelet time, antithrombin III, fibrin-monomeric complexes and products of degradation fibrinogen/fibrin were studied in 127 APSGN patients. Autocoagulation, prothrombin and thrombin tests were made. RESULTS: Progredient thrombinemia, stable elevation of Willebrand's factor, high aggregation activity of platelets and content of their degradation products evidence for intrarenal microthrombogenesis in APSGN, confirms direct involvement of platelet hemostasis in long-term inflammation in this disease. CONCLUSION: Mechanisms of APSGN development operate also through changes in hemostatic system.