Design and performance analysis of a new inferior vena cava filter.

This study proposes a novel inferior vena cava filter (IVCF) design, "Lotus," aiming to enhance release stability and endothelialization. A catheter-filter-vessel model was established for IVCF property analysis, validated by comparing numerical simulations and in vitro tests. Lotus's mechanical properties were analyzed, and optimization suggestions are provided. Compared to existing clinical filters, Lotus demonstrates improved release stability and thrombus capture ability. This work suggests Lotus as a potential technical reference for improved IVCF treatment.

Feasibility and safety of Stanford A aortic dissection complete endovascular repair system in a porcine model.

BACKGROUND: Acute type A aortic dissection (ATAAD) is a catastrophic disease with high morbidity and mortality. Although open surgery is still the gold standard for the treatment of ATAAD, some patients, with advanced age and multiple comorbidities, can only receive medical management alone. Nowadays, thoracic aortic endovascular repair (TEVAR) provides a potential treatment option for the patient with ATAAD, but traditional stent grafts (SGs), which are not designed for the ATAAD, are inapplicable to the unique anatomy of the aortic arch. Therefore, we innovatively created the BRIDGE system (Chuangxin Medical, Shenzhen, China), a complete endovascular reconstruction system designed to treat ATAAD. This study aimed to evaluate the feasibility and safety of the novel Stanford A aortic dissection complete endovascular reconstruction system in a porcine model. METHOD: The BRIDGE system consists of the type A stent system and the type C stent system. Between November 2020 and March 2021, three white swine were utilized in the study. The BRIDGE system was deployed via the transcatheter approach under angiographic guidance. The swine(n = 3) treated with our system were evaluated using angiography before sacrifice 1-month after implantation, which was followed by gross specimen evaluation and histological examination of harvested tissues. RESULT: The acute procedure success rate was 100% (3/3). The immediate post-procedural angiography showed that both type A SGs and type C SGs were deployed in satisfactory locations, with patency of the supra-aortic trunk and no endoleak. The cumulative mortality of 30-day was 0% without any adverse events. No device migration or leakage was observed angiographically, before sacrifice. The gross observation confirmed a type A SG covered part of the entry of anonyma. Favorable endothelialization, no thrombogenesis, and slight inflammatory infiltration of the tissues around the device were confirmed by microscopic examinations in all pigs. CONCLUSION: It was feasible and secure to use Stanford A aortic dissection complete endovascular reconstruction system to implement a transcatheter endovascular repair in a porcine model. With this novel system, treating acute type A aortic dissection may be more efficient and secure in human.

The optimal structural analysis of cobalt-chromium alloy (L-605) coronary stents.

A coronary stent is a conventional medical device used in percutaneous coronary intervention (PCI), and its mechanical properties have become one of the critical factors to determine the effect of surgical treatment. Based on the existing cobalt-chromium (CO-Cr) alloy L605 coronary stent, this paper established an integrated finite element model of the stent-balloon-compression shell to simulate the stent bundle expansion test and crush resistance test with parallel plates. We verified the accuracy of the analytical model by comparing the simulation results with experimental results. The effects of different parameters on the axial retraction performance, the expansion uniformity, and the flexibility of the stent are analyzed by using the support body dimension and connector form as parameters. The results demonstrate that increasing the number and length of the circumferential support can improve the axial retraction performance, expansion uniformity, and the form of the connector has a significant influence on the flexibility of the stent. Finally, the optimized CO-Cr alloy stent with improved comprehensive indicators is described.