RESUMO
Vivien Thomas was born into humble beginnings in Iberia, Louisiana in 1910. The circumstances of that era prevented him from achieving his goal of attending medical school. He became a surgical research technician at Vanderbilt Medical School. While at Vanderbilt, he began working under Alfred Blalock, one of the famous surgeons of that era. When Blalock left Vanderbilt, he asked Thomas to come with him. At Hopkins, the surgical procedure known as the Blalock-Taussig Shunt was developed to treat a serious congenital heart defect known as Tetralogy of Fallot. Vivien Thomas was instrumental in the development of that procedure.
RESUMO
Paraneoplastic syndromes can occur in 8% to 20% of individuals with malignancies. They can occur in a variety of cancers that include breast, gastric, leukemia, lung, ovarian, pancreatic, prostate, testicular, as well as kidney. The classic presentation of the triad of mass, hematuria, and flank pain occurs in less than 15% of patients with renal cancer. Because of the protean presentations of renal cell cancer, it has been referred to as the internist's tumor or the great masquerader. This article will provide a review of the causes of these symptoms.
Assuntos
Carcinoma de Células Renais , Neoplasias Renais , Síndromes Paraneoplásicas , Masculino , Humanos , Carcinoma de Células Renais/patologia , Neoplasias Renais/complicações , Neoplasias Renais/diagnóstico , Neoplasias Renais/patologia , Síndromes Paraneoplásicas/diagnóstico , Síndromes Paraneoplásicas/etiologiaRESUMO
The history of prostate cancer treatment is filled with progress over the past 120 years. The understanding of the role of testosterone in the genesis of prostate cancer continues to evolve. Diagnostic testing and the treatment of localized and metastatic prostate cancer have undergone major changes over recent decades and have transformed the outlook for patients with prostate cancer. This article reviews the major milestones of prostate cancer research and its impact on clinical care.
Assuntos
Neoplasias da Próstata , Testosterona , Masculino , Humanos , Testosterona/uso terapêutico , Antígeno Prostático Específico , Neoplasias da Próstata/patologiaRESUMO
Aside from nonmelanoma skin cancer, prostate cancer is the most common cancer among men in the United States, and benign prostatic hyperplasia is the most common benign tumor found in men. Until recently, its endocrine functions and possible influence on the hypothalamic-pituitary axis have been relatively understudied. This review summarizes the current understanding of the potential endocrine functions of prostate cancer and benign prostate tissue.
