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1.
Cereb Cortex ; 31(8): 3856-3871, 2021 07 05.
Artigo em Inglês | MEDLINE | ID: mdl-33825852

RESUMO

Cognitive performance in children is predictive of academic and social outcomes; therefore, understanding neurobiological mechanisms underlying individual differences in cognition during development may be important for improving quality of life. The belief that a single, psychological construct underlies many cognitive processes is pervasive throughout society. However, it is unclear if there is a consistent neural substrate underlying many cognitive processes. Here, we show that a distributed configuration of cortical surface area and apparent thickness, when controlling for global imaging measures, is differentially associated with cognitive performance on different types of tasks in a large sample (N = 10 145) of 9-11-year-old children from the Adolescent Brain and Cognitive DevelopmentSM (ABCD) study. The minimal overlap in these regionalization patterns of association has implications for competing theories about developing intellectual functions. Surprisingly, not controlling for sociodemographic factors increased the similarity between these regionalization patterns. This highlights the importance of understanding the shared variance between sociodemographic factors, cognition and brain structure, particularly with a population-based sample such as ABCD.


Assuntos
Córtex Cerebral/anatomia & histologia , Córtex Cerebral/fisiologia , Cognição/fisiologia , Adolescente , Desenvolvimento do Adolescente , Criança , Feminino , Humanos , Estudos Longitudinais , Imageamento por Ressonância Magnética , Masculino , Testes Neuropsicológicos , Desempenho Psicomotor/fisiologia , Sensibilidade e Especificidade , Fatores Sociodemográficos
2.
J Anim Sci ; 93(5): 2083-93, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-26020304

RESUMO

Body weight and adiposity are determined by the balance between energy intake, energy expenditure, and nutrient deposition. We have identified differences in appetite-regulating peptides in sheep selectively bred to be either lean or fat, wherein gene expression for orexin and melanin-concentrating hormone are elevated in the lean group. Despite this, the underlying mechanisms leading to differences in body composition in the lean and fat lines remains unknown. We measured postprandial temperature in adipose tissue and muscle to ascertain whether a difference in thermogenesis is associated with the difference in body composition in genetically lean (n = 8) and fat (n = 12) ewes. Body weight was higher (P < 0.01) but percent fat mass was lower (P < 0.001) in the lean group. The percent lean mass was similar in lean and fat groups. Animals received intracerebroventricular cannulae and temperature probes implanted into the retroperitoneal fat and the hind-limb skeletal muscle (vastus lateralis). Animals were meal fed (1100-1600 h) to entrain postprandial thermogenesis. Food intake was similar between lean and fat animals. Postprandial thermogenesis was greater (P < 0.05) in the retroperitoneal adipose tissue of lean animals but not in skeletal muscle. Intracerebroventricular infusion of leptin reduced (P< 0.05) food intake by an equal extent in both groups. Postprandial expression of UCP1 mRNA was greater (P < 0.05) in retroperitoneal fat of lean animals, with similar UCP3 expression in skeletal muscle. Mitochondrial genome sequencing indicated haplotypic clustering in lean and fat animals within both the encoding and nonencoding regions. This demonstrates that differences in body composition may be underpinned by differences in thermogenesis, specifically within adipose tissue. Furthermore, thermogenic differences may be associated with specific mitochondrial DNA haplotypes, suggesting a strong genetic component inherited through the maternal lineage.


Assuntos
DNA Mitocondrial/genética , Metabolismo Energético/fisiologia , Carneiro Doméstico/fisiologia , Termogênese/fisiologia , Adiposidade , Animais , Apetite , Composição Corporal , Temperatura Corporal , Peso Corporal , Ingestão de Alimentos/fisiologia , Ingestão de Energia/fisiologia , Feminino , Hormônios Hipotalâmicos/metabolismo , Gordura Intra-Abdominal/metabolismo , Leptina/metabolismo , Melaninas/metabolismo , Hormônios Hipofisários/metabolismo , Período Pós-Prandial , Ovinos , Carneiro Doméstico/genética , Termogênese/genética
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